Melatonin is an neurohormone secreted by the pineal gland.
Several therapeutic possibilities for melatonin administration have
been suggested. However, clinical studies with melatonin have been
limited by lack of a delivery system capable of mimicking the
physiological release pattern of melatonin. There is an increasing
recognition that the skin can...
Most vertebrates exhibit seasonality in many life history traits. Such seasonal rhythms are temporally organized via the transduction of environmental cues (e.g., photoperiod, temperature) into appropriate endocrine signals. However, among ectothermic vertebrates that undergo continuous winter dormancy, temperature is the only environmental cue available for synchronizing seasonal rhythms. Most intriguing...