Age-related decline in the capacity of endogenous antioxidant systems
complicates pharmaceutical use by the elderly by potentially increasing the toxicity of
some compounds. Of particular interest is chemical detoxification via glutathione (GSH)
and attendant GSH-requiring detoxification enzymes, e.g. GSH peroxidases (GPX) and
GSH S-transferase (GST). These enzymes have been shown...
Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
Researchers of healthy aging have determined trends between a species’ body mass and its maximal life span (MLSP). Actual MLSPs are then compared to predicted MLSPs and reported as a longevity quotient (LQ). Long-lived mammals, such as humans and naked mole rats (NMR), have LQs ranging from 5.0 to 10.0,...
Cuphea laminuligera Koehne and Cuphea lutea Rose in Koehne are
undomesticated species having potential as oilseed crops. Genetic
markers and mating systems have not been described for these
species. Our objectives were to survey these species for allozyme
variation, analyze the segregation and linkage of polymorphic loci,
estimate autofertility and...
Eukaryotic cells have developed elaborate biochemical processes to counteract oxidative stress, electrophiles, or carcinogens due to environmental insults. One of these important cellular defense mechanisms is mediated by the transcription factor Nrf2 that have been shown to have decrease activity with age. While the process of which Nrf2 is involved...
Small molecule metabolomics is a promising new field in medicine. Studying the chemical effects of individual cellular processes is a powerful approach in determining physiological impacts of various factors such as age, cancer stage, and genetic variability at a cellular level. However, the reactive nature and small size of many...
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resolubulized in respective solvents
Menadione
Pyruvate
α-Ketoglutarate
Resin Binding of Hydrazone
Small molecule metabolomics is a promising new field in medicine. Studying the chemical effects of individual cellular processes is a powerful approach in determining physiological impacts of various factors such as age, cancer stage, and genetic variability at a cellular level. However, the reactive nature and small size of many...
Full Text:
model compounds formed and
resolubulized in respective solvents
Menadione
Transcription factor (TF) genes were modified endogenously to include epitope tags for identification of TF protein binding sites by Chromatin Immunoprecipitation (ChIP), followed by high throughput sequencing. We used RNA-sequencing in carbon sources of sucrose, butyrate, and oleate in far-1, far-2, and a double far-1; far-2 mutant to find transcripts...
Compounds belonging to the vitamin K family possess anti-hemorrhagic
property, and are used in treating patients suffering
from hypoprothrombinemia and obstructive jaundice. Some of
these compounds also exhibit marked antimicrobial activity toward
various microorganisms. Vitamin K₅, 4-amino-2-methyl-
1-naphthol hydrochloride, a water-soluble analog of vitamin K
has been shown to possess...
