The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational change because it is a
long lifetime, visible wavelength fluorophore that is small enough to be incorporated during ribosomal biosynthesis. Incorporation
of Acd into proteins expressed in E. coli requires efficient chemical synthesis to produce large quantities...
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Christopher Lanci of the UPenn Biological Chemistry Resource
Center for assistance with automated peptide
"What’s wrong with this AI?" Explainable AI (XAI) researchers are moving beyond explaining an AI’s actions, to helping users detect an AI’s failures. However this detection may not be enough—for actionability, we often need to pinpoint which part failed. We investigate how AAR/AI, a structured assessment process, supports users with...
Archaeological investigations at the Cooper's Ferry site in Western Idaho have recovered cultural remains dating to 16,000 years ago, suggesting the oldest human occupation recorded in North America. However, many archaeologists have argued the initial peopling of North America occurred no earlier than the opening of an ice-free corridor between...