Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
Paper-based microfluidic assays, like the common pregnancy test, allow for rapid screening at the point- of-care at low cost and with no instrumentation. Fabric has many similar properties to paper, but is more flexible and durable, making it a promising option for use in a variety of diagnostic and screening...
Ph.D. candidate Qi Wei's thesis consists of two projects: Chemotherapy Project: a study based on the research paper "Predicting chemotherapy response of various cancer types using a variational auto-encoder approach" submitted to the bioRxiv preprint archive and accepted by the BMC bioinformatics; and Wound Monitor Project: implementing and assessing analytics...
This work expands the field of indoor free-space optical communication by introducing novel techniques in short range optical communication. The increasing need for high bandwidth communication necessitates the transition to optical frequencies with hundreds of terahertz worth of unregulated bandwidth. Optical communication offers an inherent security advantage over traditional communications...
Determination of the gross edge of a tumor is required during patient staging, assessing response to therapy, and for planning and executing surgical resection of locally invasive neoplasms. Disagreement in determination of the gross edge of the tumor is likely to directly affect patient staging, assessing response to therapy and...
Remote health monitoring tools have significant potential to revolutionize the current healthcare paradigm. Such tools could improve efficiencies in healthcare by alerting patients and doctors to abnormal health conditions in real time, shortening the time to diagnose and treat ailments. To meet these needs, we pursue the development of fabric-based...
Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...