BACKGROUND: Cell lineage-specific DNA methylation patterns distinguish normal human leukocyte subsets and can
be used to detect and quantify these subsets in peripheral blood. We have developed an approach that uses DNA
methylation to simultaneously quantify multiple leukocyte subsets, enabling investigation of immune modulations
in virtually any blood sample including...
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., Wiencke, J. K., Houseman, E. A., Nelson, H. H., & Kelsey, K.
T. (2014). Quantitative reconstruction of
Questions:
Popular methods to analyse community–trait–environment relationships constrain community patterns by trait and environment relationships. What if some traits are strongly associated with community composition but unrelated to environmental variables and vice versa? We take a different approach, unconstrained by this assumption using non-parametric methods. We applied this technique to...
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environmental and fire
age gradients
Peter R. Nelson, Bruce McCune, Carl Roland & Sarah Stehn
Keywords
Alaska
Because of their unique physiology, lichen communities are highly sensitive to climatic conditions, making them ideal bioindicators for climate change. Southeast and south-central Alaska host diverse and abundant lichen communities and are faced with a more rapidly changing climate than many more southerly latitudes. We develop sensitive lichen-based indicators for...
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south-central Alaska, USA
Heather T. Root
*1,3
, Bruce McCune
1
and Sarah Jovan
2
1
The origin of the late pre-industrial Holocene (LPIH) increase in atmospheric methane concentrations has been much debated. Hypotheses invoking changes in solely anthropogenic sources or solely natural sources have been proposed to explain the increase in concentrations. Here two high-resolution, high-precision ice core methane concentration records from Greenland and Antarctica...
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. Nelson, D. J. Beerling, Late Holocene methane
rise caused by orbitally controlled increase in tropical
Forest ecosystems are removing significant amounts of carbon from the atmosphere. Both abiotic resource availability and biotic interactions during forest succession affect C accumulation rates and maximum C stocks. However, the timing and controls on the peak and decline in C accumulation rates as stands age, trees increase in size,...
Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials,
but with significant inter-individual variability in its efficacy. Cytochrome P450 4F2 (CYP4F2) is the major enzyme
metabolizing Vit E, with two common genetic variants (V433M, rs2108622 and W12G, rs3093105) found to...
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; Jody Mooney, MS;
James E. Nelson, PhD; Lacey Siekas; Cheryl Shaw, MPH; Asma Siddique,
MD; Chia Wang
Grassland and shrubland birds are declining globally due in part to anthropogenic habitat modification. Because population performance of these species is also influenced by non-anthropogenic factors, it is important to incorporate all relevant ecological drivers into demographic models. We used design-based sampling and occupancy models to test relationships of environmental...
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, Ryan Mong, Brennan
Price, Mary Raikes, Sam Sellers, Edward Whitehead, MatthewWilson, and Robert Wiltzen
Terrestrial lichen biomass is an important indicator of forage availability for caribou in northern regions, and can indicate
vegetation shifts due to climate change, air pollution or changes in vascular plant community structure. Techniques for
estimating lichen biomass have traditionally required destructive harvesting that is painstaking and impractical, so we...
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and with cleaning samples. We also wish to
thank Nichole Andler for providing field crew, and Bruce
Lichens in the Arctic play important ecological roles. They also face the threats of increasing fire and shrub and tree expansion, exacerbated or caused by climate change. These forces may lead to changes not only in lichen community composition but also in the abundance, diversity and distribution of lichen functional...
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environment
Lichen traits and species as indicators of vegetation and environment
Nelson, P. R., McCune, B