BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
Information Section 1.
1. Given Name (First Name)
AlisonE.
2. Surname (Last Name)
Heald
4. Are you the
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
Nonhuman Primates and Humans
AlisonE. Heald, M.D., Jay S. Charleston, Ph.D., Patrick L. Iversen, Ph.D
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
for Marburg Virus in Nonhuman
Primates and Humans
AlisonE. Heald, M.D., Jay S. Charleston, Ph.D
Humpback whales (Megaptera novaeangliae), a mysticete with a cosmopolitan distribution, demonstrate
marked behavioural plasticity. Recent studies show evidence of social learning in the transmission of specific
population level traits ranging from complex singing to stereotyped prey capturing behaviour. Humpback
whales have been observed to employ group foraging techniques, however details...
Humpback whales (Megaptera novaeangliae), a mysticete with a cosmopolitan distribution, demonstrate
marked behavioural plasticity. Recent studies show evidence of social learning in the transmission of specific
population level traits ranging from complex singing to stereotyped prey capturing behaviour. Humpback
whales have been observed to employ group foraging techniques, however details...
Full Text:
E. Parks1, Dana A. Cusano1, Alison K. Stimpert2, Mason T. Weinrich3, Ari S. Friedlaender4
& David N