Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
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Biosynthesis
AndrewOsborn
Research Mentors: Dr. Taifo Mahmud, Dr. Kerry McPhail
A Bioresource
Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
Full Text:
By
AndrewOsborn
An Undergraduate Thesis Submitted to
Oregon State University
Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds have also been found in marine fish, where their accumulation is thought...
Air temperatures at i m and soil temperatures at 2C cm are reported for
twenty-one forest stands in the central Western Cascader of Oregon. Records
began in 1970 for some stands, in 1971 or 1972 for most. Temperature Growth
Index for a stand, based on temperature effects on Douglas-fir seedling...
Hydrographic observations made with an undulating vehicle carrying a CTD and concurrent shipboard ADCP velocity observations over a 12‐day period are combined to investigate vertical mixing and cross‐frontal fluxes on the Northern Flank of Georges Bank. The CTD density time series is analyzed to detect the presence of vertical overturns,...
Marine prey often occur in hierarchical mosaics whereby small, high-density patches
are nested inside of larger, lower density aggregations. We tested the extent to which the foraging
behavior of a marine predator (northern fur seal Callorhinus ursinus) could be explained by the
hierarchical patch structure of a dominant prey species...
Two deep ocean hotspots of turbulent mixing were found
over the Oregon continental slope. Thorpe-scale analyses
indicate time-averaged turbulent energy dissipation rates of
ε > 10⁻⁷ W/kg and eddy diffusivities of Kp ~ 10⁻² m²/s at
both hotspots. However, the structure of turbulence and its
generation mechanism at each site...