The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic
prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well
tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be...
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-Sanchez, Z., Black, C., Maier, C.
S., Williams, D. E., ... & Ho, E. (2014). SUV39H1/H3K9me3 attenuates
The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic
prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well
tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be...
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in
carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive
agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor
suppressor genes silenced...
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, Palomera-SanchezZ, Beaver LM, et al. (2014)
Effects of Sulforaphane and 3,3'-Diindolylmethane on Genome
Direct behavioral observations of multiple free-ranging animals over long periods of time and large geographic areas is
prohibitively difficult. However, recent improvements in technology, such as Global Positioning System (GPS) collars
equipped with motion-sensitive activity monitors, create the potential to remotely monitor animal behavior.
Accelerometer-equipped activity monitors quantify animal motion...
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. & Sanchez, D. M. (2014). Causes and Consequences of Timing
Errors Associated With Global Positioning System
Dispersing hydrophilic nanofillers in highly hydrophobic polymer matrices is widely used to tune the mechanical properties of composite material systems. The ability to control the dispersion of fillers is closely related to the mechanical tunability of such composites. In this work, we investigate the physical–chemical underpinnings of how simple end-group...
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Nanocomposites
H. Samet Varol *,a, M. Alejandra Sánchez a, Hao Lu a, Joe E. Baio b, Christian Malm a, Noemi
Dispersing hydrophilic nanofillers in highly hydrophobic polymer matrices is widely used to tune the mechanical properties of composite material systems. The ability to control the dispersion of fillers is closely related to the mechanical tunability of such composites. In this work, we investigate the physical–chemical underpinnings of how simple end-group...
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Confinement in Silica 1
Nanocomposites 2
H. Samet Varol a*, M. Alejandra Sánchez a, Hao Lu a, Joe E. Baio
The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated
transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput
DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for
trimethylated histone H3 lysine 27 (H3K27me3), a...
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for the putative H3K27
methyltransferase, KMT6, a homolog of Drosophila Enhancer of zeste, E(z). The
We apply GENMOM, a coupled atmosphere–ocean climate model, to simulate eight equilibrium time
slices at 3000-year intervals for the past 21,000 years forced
by changes in Earth–Sun geometry, atmospheric greenhouse
gases (GHGs), continental ice sheets, and sea level. Simulated
global cooling during the Last Glacial Maximum
(LGM) is 3.8°C and...
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., Vertenstein, M., Worley, P. H., Yang, Z.-L. and Zhang, M.: The Community
Climate System Model Version 4, J
Combined plasmonic nanocrystals and metal–organic framework
thin-films are fabricated for sensing gases in the near-infrared
range. This nanocomposite thin-film shows a highly sensitive response
in near-infrared absorption, which is attributed to preconcentration
of gas molecules in metal–organic framework pores causing close
proximity to the electromagnetic fields at the plasmonic nanocrystal...
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from the substrate side, is polarized in the x-direction and propagates in
the z-direction. The
The reaction conditions for the synthesis of Cu-BTC (BTC = benzene-1,3,5-tricarboxylic acid) were elucidated using a continuous-flow microreactor-assisted solvothermal system to achieve crystal size and phase control. A high-rate synthesis of Cu-BTC metal-organic frameworks with BET surface area of more than 1600 m²/g (Langmuir surface area of more than 2000...
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streams by using a
continuous impinging jet reactor at high pressure. Carné-Sánchez
et al.9c used a