Index Catalog // ScholarsArchive@OSU

Evaluating Paratransgenesis as a Potential Control Strategy for African Trypanosomiasis

Creator:: Medlock, Jan, Atkins, Katherine E., Thomas, David N., Aksoy, Serap, and Galvani, Alison P.
Abstract:: Genetic-modification strategies are currently being developed to reduce the transmission of vector-borne diseases, including African trypanosomiasis. For tsetse, the vector of African trypanosomiasis, a paratransgenic strategy is being considered: this approach involves modification of the commensal symbiotic bacteria Sodalis to express trypanosome-resistance-conferring products. Modified Sodalis can then be driven into...
Resource Type:: Article
Full Text:: Control Strategy for African Trypanosomiasis Jan Medlock1,2*, Katherine E. Atkins2, David N. Thomas2

Pathological and Behavioral Manifestations of the “Cayuga Syndrome,” a Thiamine Deficiency in Larval Landlocked Atlantic Salmon

Creator:: Fisher, Jeffrey P., Spitsbergen, Jan M., Iamonte, Tina, Little, Edward E., and Delonay, Aaron
Abstract:: The “Cayuga syndrome” is a maternally transmitted, naturally occurring thiamine deficiency that causes 100% mortality of larval landlocked Atlantic salmon Salmo salar in several of New York's Finger Lakes, Results of multiyear studies to qualify and quantify the neurobehavioral and gross pathological signs of this condition are described, Affected sac...
Resource Type:: Article
Full Text:: Larval Landlocked Atlantic Salmon JEFFREY P. FISHER, 1,2 JAN M. SPITSBERGEN,1,3 AND TINA IAMONTE

Activity of Meadowfoam (Limnanthes alba) Seed Meal Glucolimnanthin Degradation Products against Soilborne Pathogens

Creator:: Zasada, Inga A., Weiland, Jerry E., Reed, Ralph L., and Stevens, Jan F.
Abstract:: Meadowfoam (Limnanthes alba L.) is a herbaceous winter spring annual grown as a commercial oilseed crop. The meal remaining after oil extraction from the seed contains up to 4% of the glucosinolate glucolimnanthin. Degradation of glucolimnanthin yields toxic breakdown products, and therefore the meal may have potential in the management...
Resource Type:: Article
Full Text:: Glucolimnanthin Degradation Products against Soilborne Pathogens Inga A. Zasada,*,† Jerry E. Weiland,† Ralph L

Spatial anatomy of species driven survival: Effects of predation and climate-driven environmental variability

Creator:: Cianelli, Lorenzo, Dingsør, Gjert E., Bogstad, Bjarte, Ottersen, Geir, Chan, Kung-sik, Gjøsæter, Harald, Stiansen, Jan Erik, and Stenseth, Nils C.
Abstract:: The majority of survival analyses focus on temporal scales. Consequently, there is a limited understanding of how species survival varies over space and, ultimately, how spatial variability in the environment affects the temporal dynamics of species abundance. Using data from the Barents Sea, we study the spatiotemporal variability of the...
Resource Type:: Article
Full Text:: CLIMATE-DRIVEN ENVIRONMENTAL VARIABILITY LORENZO CIANNELLI,1,5 GJERT E. DINGSøR,1,2 BJARTE BOGSTAD,3 GEIR

The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro

Creator:: Marley, Kevin, Helfand, Stuart C., Edris, Wade A., Mata, John E., Gitelman, Alix I., Medlock, Jan, and Seguin, Bernard
Abstract:: Background: Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6–12 months despite these treatments. Taurolidine, a derivative of taurine, has...
Resource Type:: Article
Full Text:: osteosarcoma in vitro Kevin Marley1, Stuart C Helfand1, Wade A Edris1,4, John E Mata2, Alix I Gitelman3, Jan

SpitsbergenJanMicrobiologyOncogenicKRASPromotes_AdditionalFiles.pdf

Creator:: Ju, Bensheng, Chen, Wenbiao, Orr, Brent A., Spitsbergen, Jan M., Jia, Sujuan, Eden, Christopher J., Henson, Hannah E., and Taylor, Michael R.
Abstract:: BACKGROUND: Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most...
Full Text:: MPNST-like tumors. (A) H&E staining of sagittal section from a 6-month-old fish showing a large tumor

SpitsbergenJanMicrobiologyOncogenicKRASPromotes.pdf

Creator:: Ju, Bensheng, Chen, Wenbiao, Orr, Brent A., Spitsbergen, Jan M., Jia, Sujuan, Eden, Christopher J., Henson, Hannah E., and Taylor, Michael R.
Abstract:: BACKGROUND: Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most...
Full Text:: Oncogenic KRAS promotes malignant brain tumors in zebrafish Bensheng Ju1, Wenbiao Chen2, Brent A Orr3, Jan M

CUE final poster 5-13-14 - Kim Kelsey.pptx

Creator:: Kelsey, Kimberly J., Atwell, Lauren L., Clarke, John D., Hsu, Anna, Bella, Deborah, Stevens, Jan F., Dashwood, Roderick H., Williams, David E., and Ho, Emily
Abstract:: Consuming cruciferous vegetables such as broccoli sprouts, kale, Brussels sprouts, and bok choy is associated with several health benefits, such as a decreased risk of certain cancers. Cruciferous vegetables contain the glucosinolate, glucoraphanin (GFN). Cutting, chopping or chewing these vegetables releases the enzyme myrosinase, which transforms GFN into sulforaphane (SFN)....
Full Text:: Bella1, Jan F. Stevens2,3, Roderick H. Dashwood2,4, David E. Williams2,4, and Emily Ho1,2 1School of

CUE final poster 5-13-14 - Kim Kelsey.pdf

Creator:: Kelsey, Kimberly J., Atwell, Lauren L., Clarke, John D., Hsu, Anna, Bella, Deborah, Stevens, Jan F., Dashwood, Roderick H., Williams, David E., and Ho, Emily
Abstract:: Consuming cruciferous vegetables such as broccoli sprouts, kale, Brussels sprouts, and bok choy is associated with several health benefits, such as a decreased risk of certain cancers. Cruciferous vegetables contain the glucosinolate, glucoraphanin (GFN). Cutting, chopping or chewing these vegetables releases the enzyme myrosinase, which transforms GFN into sulforaphane (SFN)....
Full Text:: L. Atwell1,2, John D. Clarke1, Anna Hsu1, Deborah Bella1, Jan F. Stevens2,3, Roderick H. Dashwood2,4

Oncogenic KRAS promotes malignant brain tumors in zebrafish

Creator:: Ju, Bensheng, Chen, Wenbiao, Orr, Brent A., Spitsbergen, Jan M., Jia, Sujuan, Eden, Christopher J., Henson, Hannah E., and Taylor, Michael R.
Abstract:: BACKGROUND: Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most...
Resource Type:: Article

ScholarsArchive@OSU

Evaluating Paratransgenesis as a Potential Control Strategy for African Trypanosomiasis

Pathological and Behavioral Manifestations of the “Cayuga Syndrome,” a Thiamine Deficiency in Larval Landlocked Atlantic Salmon

Activity of Meadowfoam (Limnanthes alba) Seed Meal Glucolimnanthin Degradation Products against Soilborne Pathogens

Spatial anatomy of species driven survival: Effects of predation and climate-driven environmental variability

The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro

SpitsbergenJanMicrobiologyOncogenicKRASPromotes_AdditionalFiles.pdf

SpitsbergenJanMicrobiologyOncogenicKRASPromotes.pdf

CUE final poster 5-13-14 - Kim Kelsey.pptx

CUE final poster 5-13-14 - Kim Kelsey.pdf

Oncogenic KRAS promotes malignant brain tumors in zebrafish

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