Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
As we contemplate the future of forest landscapes under changing climate conditions and land-use demands, there is increasing value in studying historic forest conditions and how these landscapes have changed following past disturbances. Historic landscape paintings are a potential source of data on preindustrial forests with highly detailed, full-color depictions...
These datasets were used in the prospective meta-analysis of northern spotted owl reproductive rates over 25 years across 11 study areas located throughout the range of the owl. A multi-state occupancy file was created by collapsing site-specific information on owl reproductive status into bimonthly (2 per month) survey occasions. These...
Photosynthetic diatoms and marine bacteria contribute about one third of the net primary production in marine environments. Understanding the interactions between these two organisms is potentially important to the over all flow of carbon in the marine ecosystem.
These datasets were used in the prospective meta-analysis of northern spotted owl reproductive rates over 25 years across 11 study areas located throughout the range of the owl. A multi-state occupancy file was created by collapsing site-specific information on owl reproductive status into bimonthly (2 per month) survey occasions. These...
These datasets were used in the prospective meta-analysis of northern spotted owl reproductive rates over 25 years across 11 study areas located throughout the range of the owl. A multi-state occupancy file was created by collapsing site-specific information on owl reproductive status into bimonthly (2 per month) survey occasions. These...
For many historical and contemporary experimental studies in marine biology, seawater carbonate chemistry remains a ghost factor, an uncontrolled, unmeasured, and often dynamic variable affecting experimental organisms or the treatments to which investigators subject them. We highlight how environmental variability, such as seasonal upwelling and biological respiration, drive variation in...
A critical barrier to effective management of deep-sea resources is a lack of understanding by society of the benefits received from the oceans. To address this knowledge gap, we applied an iterative design-based research methodology to evaluate (1) how to effectively use an exhibit to increase public literacy of the...
Headwater streams and wetlands are integral components of watersheds that are critical for biodiversity, fisheries, ecosystem functions, natural resource-based economies, and human society and culture. These and other ecosystem services provided by intact and clean headwater streams and wetlands are critical for a sustainable future. Loss of legal protections for...
Despite progressive policies and continued advances in ocean management, numerous shifts associated with global changes have been observed in marine ecosystems in recent years, including warming, ocean acidification, and deoxygenation. As global change accelerates, science is needed to inform evidence-based management strategies for continued ecosystem services. Resilience management, in which...