Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
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Manner in mdx Mice
Limin Cao1,2, Gang Han1, Caorui Lin1, Ben Gu1, Xianjun Gao1, Hong M Moulton3, Yiqi
Optical variability occurs in the near-surface and upper ocean on very short time and space scales (e.g., milliseconds and millimeters and less) as well as greater scales. This variability is caused by solar, meteorological, and other physical forcing as well as biological and chemical processes that affect optical properties and...
"The Shellfish Investigation samples the crab catch along the Oregon coast each year for shell condition as an index to meat yield and suitability of season opening dates. In addition to sampling for condition, a number of animals are sampled for width frequencies to determine the mean size of crabs...
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence...
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Shen, Richard I. Gregory, George Q. Daley, Alexander
Meissner, Manolis Kellis, Konrad Hochedlinger
Pseudoperonospora cubensis is an obligate pathogen and
causative agent of cucurbit downy mildew. To help advance
our understanding of the pathogenicity of P. cubensis, we
used RNA-Seq to improve the quality of its reference
genome sequence. We also characterized the RNA-Seq
dataset to inventory transcript isoforms and infer alternative
splicing...
Controversial end member models for the growth and evolution of the Tibetan Plateau demand quantitative constraints of the lithospheric rheology. Direct determinations of bulk crustal rheology, however, remain relatively sparse. Here we use the flexural rebound of lacustrine shorelines developed during the Lingtong highstand around Siling Co, in central Tibet,...
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lateral flow of the deep crust (Bird, 1991; 53
Royden et al., 1997; Royden et al., 2008; Shen et al
The effects of hydrogen sulfide (H2S) on storage quality, cellular water distribution, and cell wall metabolism of strawberry fruit after subjected to shelf or cold storage were investigated. Fruit were fumigated with a range of aqueous NaHS solution (0.4-3.2 mmol/L), then stored at 20 degrees C for 3 d or...
Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirg locus, which is essential for full pluripotency of iPSCs. In the absence...
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Choe,8 Don Leong Jia Jun,1,9 Xiaohua Shen,1,15 Richard I. Gregory,8
George Q. Daley,1,2 Alexander