Despite recent efforts to improve site safety, construction still accounts for a disproportionate injury and illness rate. According to the 2007 injury and illness data released by the National Safety Council, the construction industry has a fatality and disabling injury rate that is approximately three times higher than the all-industry...
Nanotechnologies continue to permeate a multitude of industries, with diverse applications ranging from pesticides to fuel additives. The unusual behavior of nanomaterials that drives their innovation also complicates the job of toxicologists tasked with assessing their potential environmental and public health impacts. This dissertation investigates the underlying reasons for uncertainty...
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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,14 Tom Darden,15 Paul Emsley,16 Victoria A. Feher,17,* Zukang Feng,5,6 Colin R. Groom,18,*
Seth F
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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L. Clark, Tom Darden, Paul
Emsley, Victoria A. Feher, Zukang Feng, Colin R. Groom, Seth F. Harris
Advancing the understanding of natural resource management is an important step in mitigating the effects of human activity on the environment, and ensuring efficient outcomes for many sectors of the economy. As humanity’s role in the natural world becomes better understood, the importance of interdisciplinary modeling has grown in leaps...
The volcanic origin of the Samoan archipelago can be explained by one of three models, specifically, by a hot spot forming over a mantle plume, by lithospheric extension resulting from complex subduction tectonics in the region, or by a combination of these two processes, either acting sequentially or synchronously. In...
Oncorhynchus mykiss form partially migratory populations with anadromous fish that undergo marine migrations and residents that complete their life cycle in fresh water. Many populations’ anadromous components are threatened or endangered, prompting interest in understanding ecological and evolutionary processes underlying anadromy and residency. In this paper, we synthesize information to...
The measurement of phytoplankton carbon (C[subscript]phyto) in the field has been a long-sought but elusive goal in oceanography. Proxy measurements of C[subscript]phyto have been employed in the past, but are subject to many confounding influences that undermine their accuracy. Here we report the first directly measured C[subscript]phyto values from the...
This research examines the effect of recent landownership changes and new management stewardship mechanisms (e.g., forest certification and working forest conservation easements) on disturbance rates in Maine forests. We quantify forest disturbance rates between 2000 and 2007 and forest cover type composition in 2007, as detected by Landsat Thematic Mapper...
We previously reported that inhibition of the Na⁺ translocating NADH:ubiquinone oxidoreductase (NQR), either by chemical inhibition or mutation, increased toxT transcription in Vibrio cholerae. In this study, we revealed that the nqr mutant strain showed similar phenotypes as the Escherichia coli NADH dehydrogenase I (nuo) mutant strain (e.g. growth defect...
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Sara R. Fassio1, Yusuke Minato2, Matthew J. Quinn1, Wyatt J. Faulkner1 and