A central goal of green chemistry is to avoid hazard in the design of new chemicals. This objective is best achieved when information about a chemical's potential hazardous effects is obtained as early in the design process as feasible. Endocrine disruption is a type of hazard that to date has...
microRNAs (miRNAs) have emerged as regulators of a broad spectrum of neurodevelopmental processes, including brain morphogenesis, neuronal differentiation, and survival. While the role of miRNAs in establishing and maintaining the developing nervous system is widely appreciated, the developmental neurobehavioral role of miRNAs has yet to be defined. Here we show...
Many carbon nanotube (CNT) applications require precisely controlled chemical
functionalization that is minimally disruptive to electrical performance. A promising approach is
the generation of sp³ hybridized carbon atoms in the sp²-bonded lattice. We have investigated the
possibility of using a carboxylic acid functionalized diazonium reagent to introduce a defined
number...
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Nanotubes
Heather Wilson, Sophie Ripp, Landon Prisbrey, Morgan Brown, Tal Sharf,
Daniel J. T. Myles
Many carbon nanotube (CNT) applications require precisely controlled chemical
functionalization that is minimally disruptive to electrical performance. A promising approach is
the generation of sp³ hybridized carbon atoms in the sp²-bonded lattice. We have investigated the
possibility of using a carboxylic acid functionalized diazonium reagent to introduce a defined
number...
Full Text:
Individual Carbon
Nanotubes
Wilson, H., Ripp, S., Prisbrey, L., Brown, M. A., Sharf, T., Myles, D. J
Many carbon nanotube (CNT) applications require precisely controlled chemical functionalization that is minimally disruptive to electrical performance. A promising approach is the generation of sp³ hybridized carbon atoms in the sp²-bonded lattice. We have investigated the possibility of using a carboxylic acid functionalized diazonium reagent to introduce a defined number...
As a persistent organic contaminant, perfluorooctanesulphonic acid (PFOS) has been widely detected in the environment, wildlife, and humans. The present study revealed that zebrafish embryos exposed to 16 µM PFOS during a sensitive window of 48-96 hour post-fertilization (hpf) disrupted larval morphology at 120 hpf. Malformed zebrafish larvae were characterized...
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by Treatment
PFOS
Control
p05, 5% FDR
T-test
PFOS Control
p05, 5% FDR, 2
As a persistent organic contaminant, perfluorooctanesulphonic acid (PFOS) has been widely detected in the environment, wildlife, and humans. The present study revealed that zebrafish embryos exposed to 16 µM PFOS during a sensitive window of 48-96 hour post-fertilization (hpf) disrupted larval morphology at 120 hpf. Malformed zebrafish larvae were characterized...
Full Text:
zebrafish organogenesis
Chen, J., Tanguay, R. L., Tal, T. L., Gai, Z., Ma, X., Bai, C., ... & Dong, Q
Background: MicroRNAs (miRNAs) are noncoding RNAs that direct post-transcriptional regulation of protein coding genes. Recent studies have shown miRNAs are important for controlling many biological processes, including nervous system development, and are highly conserved across species. Given their importance, computational tools are necessary for analysis, interpretation and integration of high-throughput...
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, lighting and ethanol.
Neurotoxicology 30, 52-58
Tal, T. L., J. A. Franzosa, et al. (2012). "MicroRNAs
Background: MicroRNAs (miRNAs) are noncoding RNAs that direct post-transcriptional regulation of protein coding genes. Recent studies have shown miRNAs are important for controlling many biological processes, including nervous system development, and are highly conserved across species. Given their importance, computational tools are necessary for analysis, interpretation and integration of high-throughput...
Background: MicroRNAs (miRNAs) are noncoding RNAs that direct post-transcriptional regulation of protein coding genes. Recent studies have shown miRNAs are important for controlling many biological processes, including nervous system development, and are highly conserved across species. Given their importance, computational tools are necessary for analysis, interpretation and integration of high-throughput...