Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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, 7.
Henderson, R., Sali, A., Baker, M.L., Carragher, B., Devkota, B., Downing, K.H., Egelman, E.H
This project deals with a method to optimize in vivo labeling using small fluorescent molecules via bioorthogonal reactions. The reaction used involves our unnatural amino acid 4-(6-methyl-s-tetrazin-3-yl)aminophenylalanine (AMT-Phe). The amino acid is site-specifically incorporated into GFP and then reacted with a labeled, strained trans-cyclooctene, resulting in a labeled protein. However...
This project deals with a method to optimize in vivo labeling using small fluorescent molecules via bioorthogonal reactions. The reaction used involves our unnatural amino acid 4-(6-methyl-s-tetrazin-3-yl)aminophenylalanine (AMT-Phe). The amino acid is site-specifically incorporated into GFP and then reacted with a labeled, strained trans-cyclooctene, resulting in a labeled protein. However...
This project deals with a method to optimize in vivo labeling using small fluorescent molecules via bioorthogonal reactions. The reaction used involves our unnatural amino acid 4-(6-methyl-s-tetrazin-3-yl)aminophenylalanine (AMT-Phe). The amino acid is site-specifically incorporated into GFP and then reacted with a labeled, strained trans-cyclooctene, resulting in a labeled protein. However...
This project deals with a method to optimize in vivo labeling using small fluorescent molecules via bioorthogonal reactions. The reaction used involves our unnatural amino acid 4-(6-methyl-s-tetrazin-3-yl)aminophenylalanine (AMT-Phe). The amino acid is site-specifically incorporated into GFP and then reacted with a labeled, strained trans-cyclooctene, resulting in a labeled protein. However...
We are studying the impacts of parasites on threatened stocks of Oregon coastal coho
salmon (Oncorhynchus kisutch). In our previous studies, we have found high infections of
digeneans and myxozoans in coho salmon parr from the lower main stem of West Fork Smith
River (WFSR), Oregon. In contrast parr from...
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survival by decreasing
predator avoidance (Taylor and McPhail, 1985). Osmoregulation is an
important factor
In recent years, depletion of sands in the nearshore environment along the northern Oregon and southwest Washington coasts has been documented. This erosion raises concerns about protection of economic and ecological resources in the area. The Columbia River Nearshore Beneficial Use Project was initiated to engage public and private sector...
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. 86:417-432.
Barlow, J. C.W. Oliver, T.D. Jackson, and B.L. Taylor. 1988. Harbor porpoise
Cadmium is a common impurity in phosphatic fertilizers and may contribute to soil Cd accumulation. Changes in total and bioavailable Cd burdens to agricultural soils and the potential for plant Cd accumulation resulting from fertilizer input was investigated. Three year field studies were conducted using three dose levels of cadmium-rich,...
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, while even higher levels are found in leafy vegetables and
potatoes (Taylor et al., 1998). The total
Conservation investment in management of at-risk species can be less costly than a delay-and-repair approach implemented after species receive legal protection. The United States Endangered Species Act candidate species designation represents an opportunity to implement proactive management to avoid future listing. Such efforts require substantial investments, and the challenge becomes...
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species of conservation concern (Czech and Kraus-
man, 2001; Taylor et al., 2005; Schwartz, 2008; Harris
Conservation investment in management of at-risk species can be less costly than a delay-and-repair
approach implemented after species receive legal protection. The United States Endangered Species
Act candidate species designation represents an opportunity to implement proactive management to
avoid future listing. Such efforts require substantial investments, and the challenge becomes...
Full Text:
protection for species of conservation concern (Czech and Kraus-
man, 2001; Taylor et al., 2005; Schwartz