Aquaculture in Vietnam has a long tradition. So far, this industry has been dominated by fresh water and brackish water aquaculture. Cage culture in marine waters has been developed more recently. With a coastline of 3260 km and an Exclusive Economic Zone (EEZ) of more than one million square km,...
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing
trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor
prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc
orthologs, myca and mycb, it remains unclear about the oncogenicity of...
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in tp53 Null Mutation
Lili Sun1, AnhTuan Nguyen1¤, Jan M. Spitsbergen2, Zhiyuan Gong1*
1Department
Economic indicators are needed for future knowledge-based fisheries management in Vietnam. This entails a good data collecting and processing system. This paper contributes to this requirement for the tuna-mackerel gillnet fishery, near-shore and offshore, in Nha Trang, South-Central Vietnam. For 2005 and 2006 fifty vessels were surveyed for technical characteristics,...
Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the kras(V12) oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation between zebrafish and human liver tumorigenesis, the low tumor incidence and early mortality...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant, and suppresses many disease models including graft-versus-host (GVH), experimental autoimmune encephalomyelitis (EAE) and a model of type 1 diabetes in non-obese diabetic (NOD) mice (1-3). In this study, we show that the inflammation of the pancreas due to insulitis is not a systemic autoimmune...
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insulitis in NOD
mice
Tuan Pham
Dr. Nancy Kerkvliet
Environmental and Molecular Toxicology
Oregon State
Vietnam’s marine fisheries are in need of knowledge-based management. This necessitates the establishment of
reliable indicators, which in turn entails a good data collecting and processing system. To bridge the gap between
specific requirements for fisheries policy development and the limited resources available, we have conducted a
study on costs...
Here we report a new transgenic expression system by combination of liver-specific expression,
mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic
kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure
of mifepristone to induce permanent genomic recombination mediated by...
Full Text:
expression in transgenic zebrafish
AnhTuan Nguyen
1, 2
, Vivien Koh
1
, Jan M. Spitsbergen
2
Here we report a new transgenic expression system by combination of liver-specific expression,
mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic
kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure
of mifepristone to induce permanent genomic recombination mediated by...
Full Text:
control oncogenic krasV12
expression in transgenic zebrafish
AnhTuan Nguyen1,2, Vivien Koh1, Jan M
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing
trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor
prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc
orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Here we report a new transgenic expression system by combination of liver-specific expression, mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure of mifepristone to induce permanent genomic recombination mediated by...
