The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A.
The synthesis used a convergent approach involving...
Low reproductive success has been typical of high elevation populations of the Hawaiian goose (Branta sandvicensis) or nēnē. Researchers identified predation and inadequate nutrition as limiting factors. Reproductive success remained low in most years despite on-going predator control programs. I used a supplemental feeding program over two breeding seasons in...
Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with
a unique molecular architecture and pronounced biological activity, are described. These
studies resulted in the synthesis of advanced intermediate 208, containing all of the
carbon atoms of 1.
A Dötz annulation between alkyne 122 and novel chromium carbenoid...
These stories are an attempt to give a distinct literary voice to the people and places of rural Southern Indiana. They also strive to deal with certain elements indigenous to that region, some of which can be described generally as the tension between modernization and tradition, family and marriage as...
The population of dusky Canada geese (Branta canadensis occidentalis; hereafter, dusky geese) nesting on the western Copper River Delta (CRD) in south- central Alaska has been in decline since the late 1970s. In an effort to alleviate mammalian predation, increase nest success, and avoid a listing under the U.S. Endangered...
Lauren Fath, in her non-fiction collection Half-Life: Essays, examines the underpinnings of her upbringing in suburban Fort Wayne, Indiana, focusing primarily on familial relationships and the importance of hindsight in understanding how our families make an imprint on our lives. By looking at our relationships through the lens offered by...
The existence of generalized symmetries of Maxwell's equations in Gödel's Universe is investigated. It is shown that their existence is in turn tied to the existence of certain spinorial objects called Killing spinors.
The conformal algebra, corresponding to valence (1; 1) Killing spinors, for Gödel's Universe is discussed in detail....
The consequences of species introductions into non-native habitats are a major cause of concern in the U.S. An introduced species may alter native habitats, cause economic damage, compete with natives for resources or prey on them. Of particular interest are the effects of predation by introduced fishes on native amphibians....
This thesis is arranged in three chapters which explore Wharton’s representations of nature in three novels: The House of Mirth (1905), The Fruit of the Tree (1907), and The Custom of the County (1913). This thesis contends that Wharton’s novels reveal changes in the interplay between representations of nature and...
Chromosome counts were determined for 152 accessions of Pseudoroegneria
spicata (Pursh) A. Löve and, combined with existing count
data, used to plot the distribution of diploid and tetraploid populations.
Morphological variation of 55 characters was examined in five
groups totaling 205 operational taxonomic units (OTU's), using
cluster, principal factor, and...