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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
- Full Text:
- ,2 Cary Bauer,3 Jeffrey A. Bell,4 Helen M. Berman,5,6 Talapady N. Bhat,7 Jeff M. Blaney,8 Evan
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
- Full Text:
- Workshop Paul D. Adams, Kathleen Aertgeerts, Cary Bauer, Jeffrey A. Bell, Helen M. Berman, Talapady N
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- Creator:
- Lubchenco, Jane, Menge, Bruce A., Barth, John A., Carr, Mark H., Caselle, Jennifer E., Chan, Francis, Fulton-Bennett, Heather K., Gaines, Steven D., Kroeker, Kristy J., Milligan, Kristen, Palumbi, Steven R., and White, J. Wilson
- Abstract:
- Twenty years ago, the creation of a new scientific program, the Partnership for Interdisciplinary Studies of Coastal Oceans (PISCO), funded by the Packard Foundation, provided the opportunity to integrate—from the outset—research, monitoring, and outreach to the public, policymakers, and managers. PISCO’s outreach efforts were initially focused primarily on sharing scientific...
- Resource Type:
- Article
- Full Text:
- –8,091, https://doi.org/ 10.1073/ pnas.1231332100. Carr, M.H., J.W. White, E. Saarman, J. Lubchenco, K
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- Creator:
- Buizert, C., Martinerie, P., Petrenko, V. V., Severinghaus, J. P., Trudinger, C. M., Witrant, E., Rosen, J. L., Orsi, A. J., Rubino, M., Etheridge, D. M., Steele, L. P., Hogan, C., Laube, J. C., Sturges, W. T., Levchenko, V. A., Smith, A. M., Levin, I., Conway, T. J., Dlugokencky, E. J., Lang, P. M., Kawamura, K., Jenk, T. M., White, J. W. C., Sowers, T., Schwander, J., and Blunier, T.
- Abstract:
- Air was sampled from the porous firn layer at the NEEM site in Northern Greenland. We use an ensemble of ten reference tracers of known atmospheric history to characterise the transport properties of the site. By analysing uncertainties in both data and the reference gas atmospheric histories, we can objectively...
- Resource Type:
- Article
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- Creator:
- Tello-Ruiz, Marcela K., Stein, Joshua, Wei, Sharon, Preece, Justin, Olson, Andrew, Naithani, Sushma, Amarasinghe, Vindhya, Dharmawardhana, Palitha, Jiao, Yinping, Mulvaney, Joseph, Kumari, Sunita, Chougule, Kapeel, Elser, Justin, Wang, Bo, Thomason, James, Bolser, Daniel M., Kerhornou, Arnaud, Walts, Brandon, Fonseca, Nuno A., Huerta, Laura, Keays, Maria, Tanga, Y. Amy, Parkinson, Helen, Fabregat, Antonio, McKay, Sheldon, Weiser, Joel, D'Eustachio, Peter, Stein, Lincoln, Petryszak, Robert, Kersey, Paul J., Jaiswal, Pankaj, and Ware, Doreen
- Abstract:
- Gramene (http://www.gramene.org) is an online resource for comparative functional genomics in crops and model plant species. Its two main frameworks are genomes (collaboration with Ensembl Plants) and pathways (The Plant Reactome and archival BioCyc databases). Since our last NAR update, the database website adopted a new Drupal management platform. The...
- Resource Type:
- Article
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- Creator:
- Wannamaker, Philip E., Booker, John R., Filloux, Jean H., Jones, Alan G., Jiracek, George R., Chave, Alan D., Tarits, Pascal, Waff, Harve S., Egbert, Gary D., Young, Charles T., Stodt, John A., Martinez, Mario G., Law, Lawrie K., Yukutake, Takesi, Segawa, Jiro S., White, Anthony, and Green, A.W.
- Abstract:
- A magnetotelluric (MT)transect has been obtained near latitude 45øN from the active Juan de Fuca Spreading center, across the subduction zone and Cascades volcanic arc, and into the back arc Deschutes Basin region. This paper presents the MT data set and describes its major characteristics as they pertain to the...
- Resource Type:
- Article
- Full Text:
- , MARIO MARTINEZ G.,LAWRIE K. LAW, TAKESI YUKUTAKE, JIRO S. SEGAWA, ANTHONY WI-R'IE, AND A. W. GREEN, JR
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- Creator:
- Snyder, Kai U., Sullivan, Timothy J., Raymond, Richard B., Bischoff, Joseph M., White, Shawn, Binder, Susan K., and E & S Environmental Chemistry, Inc.
- Abstract:
- The purpose of this watershed assessment is to inventory and characterize watershed conditions of the Miami River watershed and to provide recommendations that address the issues of water quality, fisheries and fish habitat, and watershed hydrology. This assessment was conducted by reviewing and synthesizing existing data sets and some new...
- Resource Type:
- Technical Report
- Full Text:
- . Sullivan Richard B. Raymond Joseph M. Bischoff Shawn White Susan K. Binder Submitted to: Tillamook
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- Creator:
- Stein, Ruediger, Kanamatsu, Toshiya, Alvarez-Zarikian, Carlos, Higgins, Sean M., Channell, Jim E. T., Aboud, Essam, Ohno, Masao, Acton, Gary D., Akimoto, Kazumi, Bailey, Ian, Bjorklund, Kjell R., Evans, Helen, Neilsen, Simmon H. H., Ferretti, Partizia, Gruetzner, Jean, Hagino, Kentaro, Harris, Robert N., Hatakeda, Kentaro, Hefter, Jens, Judge, Shelley A., Kullanek, Denise K., Nanayama, Futoshi, Rashid, Harunur, Sierro Sanchez, Francisco J., Voelker, Antje, and Zhai, Qiumin
- Abstract:
- In the North Atlantic, cold, relatively salty water sinks in the icy Labrador and Greenland seas, forming North Atlantic Deep Water (NADW). This circulates through the global ocean, driving ocean overturning and global heat transport and, thus, impacting global climate. As one of the most climatically sensitive regions on Earth,...
- Resource Type:
- Article
- Full Text:
- . OHNO, G.D. ACTON, K. AKIMOTO, I. BAILEY, K.R. BJØRKLUND, H. EVANS, S.H.H. NIELSEN, N. FANG, P
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- Creator:
- Roberts, Blaine R., Lim, Nastasia K. H., McAllum, Erin J., Donnelly, Paul S., Hare, Dominic J., Doble, Philip A., Turner, Bradley J., Price, Katherine A., Lim, Sin Chun, Paterson, Brett M., Hickey, James L., Rhoads, Timothy W., Williams, Jared R., Kanninen, Katja M., Hung, Lin W., Liddell, Jeffrey R., Grubman, Alexandra, Monty, Jean-Francois, Llanos, Roxana M., Kramer, David R., Mercer, Julian F. B., Bush, Ashley I., Masters, Colin L., Duce, James A., Li, Qiao-Xin, Beckman, Joseph S., Barnham, Kevin J., White, Anthony R., and Crouch, Peter J.
- Abstract:
- Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an expression level-dependent phenotype in transgenic rodents. We show that oral treatment with the therapeutic agent diacetyl-bis(4-methylthiosemicarbazonato)copper[superscript II] [Cu[superscript II](atsm)] increased the concentration of mutant SOD1 (SOD1G37R) in ALS model mice, but paradoxically improved locomotor...
- Resource Type:
- Article
- Full Text:
- Amyotrophic Lateral Sclerosis Roberts, B. R., Lim, N. K. H., McAllum, E. J., Donnelly, P. S., Hare, D. J
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
- Resource Type:
- Article