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Wilson, William Joseph
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- Creator:
- Chadwick, William W., Jr., Merle, Susan G., Buck, Nathaniel J., Lavelle, J. William, Resing, Joseph A., and Ferrini, Vicki
- Abstract:
- NW Rota-1 is a submarine volcano in the Mariana volcanic arc located ~100 km north of Guam. Underwater explosive eruptions driven by magmatic gases were first witnessed there in 2004 and continued until at least 2010. During a March 2010 expedition, visual observations documented continuous but variable eruptive activity at...
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- Creator:
- Chadwick, William W., Jr., Merle, Susan G., Buck, Nathaniel J., Lavelle, J. William, Resing, Joseph A., and Ferrini, Vicki
- Abstract:
- NW Rota-1 is a submarine volcano in the Mariana volcanic arc located ~100 km north of Guam. Underwater explosive eruptions driven by magmatic gases were first witnessed there in 2004 and continued until at least 2010. During a March 2010 expedition, visual observations documented continuous but variable eruptive activity at...
- Full Text:
- Rota-1, Mariana Arc William W. Chadwick Jr.1, Susan G. Merle1, Nathaniel J. Buck2, J. William Lavelle3
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- Creator:
- Fok, Wilson C., Chen, Yidong, Bokov, Alex, Zhang, Yiqiang, Salmon, Adam B., Diaz, Vivian, Javors, Martin, Wood, William H., III, Zhang, Yongqing, Becker, Kevin G., Pérez, Viviana I., and Richardson, Arlan
- Abstract:
- Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin’s longevity effect,...
- Full Text:
- in the Liver Transcriptome Wilson C. Fok1, Yidong Chen3,4,5, Alex Bokov2,3, Yiqiang Zhang2,6, Adam B
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- Creator:
- Fok, Wilson C., Chen, Yidong, Bokov, Alex, Zhang, Yiqiang, Salmon, Adam B., Diaz, Vivian, Javors, Martin, Wood, William H., III, Zhang, Yongqing, Becker, Kevin G., Pérez, Viviana I., and Richardson, Arlan
- Abstract:
- Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin’s longevity effect,...
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- Creator:
- Fok, Wilson C., Bokov, Alex, Gelfond, Jonathan, Yu, Zhen, Zhang, Yiqiang, Doderer, Mark, Chen, Yidong, Javors, Martin, Wood, William H., III, Zhang, Yongqing, Becker, Kevin G., Richardson, Arlan, and Pérez, Viviana I.
- Abstract:
- Rapamycin (Rapa) and dietary restriction (DR) have consistently been shown to increase lifespan. To investigate whether Rapa and DR affect similar pathways in mice, we compared the effects of feeding mice ad libitum (AL), Rapa, DR, or a combination of Rapa and DR (Rapa + DR) on the transcriptome and...
- Full Text:
- dietary restriction has a larger effect on the transcriptome and metabolome of liver Wilson C. Fok,1 Alex
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- Creator:
- Fok, Wilson C., Bokov, Alex, Gelfond, Jonathan, Yu, Zhen, Zhang, Yiqiang, Doderer, Mark, Chen, Yidong, Javors, Martin, Wood, William H., III, Zhang, Yongqing, Becker, Kevin G., Richardson, Arlan, and Pérez, Viviana I.
- Abstract:
- Rapamycin (Rapa) and dietary restriction (DR) have consistently been shown to increase lifespan. To investigate whether Rapa and DR affect similar pathways in mice, we compared the effects of feeding mice ad libitum (AL), Rapa, DR, or a combination of Rapa and DR (Rapa + DR) on the transcriptome and...
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- Creator:
- Embley, Robert W., Merle, Susan G., Baker, Edward T., Dziak, Robert P., Chadwick, William W., Jr., Greene, Ron, Haxel, Joseph, and et al.
- Abstract:
- We present multiple lines of evidence for years to decade-long changes in the location and character of volcanic activity at West Mata seamount in the NE Lau basin over a 16 year period, and a hiatus in summit eruptions from early 2011 to at least September 2012. Boninite lava and...
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- Creator:
- Embley, Robert W., Merle, Susan G., Baker, Edward T., Dziak, Robert P., Chadwick, William W., Jr., Greene, Ron, Haxel, Joseph, and et al.
- Abstract:
- We present multiple lines of evidence for years to decade-long changes in the location and character of volcanic activity at West Mata seamount in the NE Lau basin over a 16 year period, and a hiatus in summit eruptions from early 2011 to at least September 2012. Boninite lava and...
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- , Kenneth H. Rubin4, John E. Lupton1, Joseph A. Resing5, Robert P. Dziak2, Marvin D. Lilley6, William W
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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- , Jorg Hendle, Thomas Holder, Andrzej Joachimiak, Gerard J. Kleywegt, Tobias Krojer, Joseph Marcotrigiano
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
- Full Text:
- digital Tobias Krojer,22 Joseph Marcotrigiano,6,23 Alan E. Mark,24 John L. Markley,25 Matthew