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Filtering by: Creator Yang, Ying, 1969- Commencement Year Unknown

Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment

Creator:

Yang, Xiuqing, Feng, Peng, Yin, Ying, Bushley, Kathryn, Spatafora, Joseph W., and Wang, Chengshu

Abstract:

The cycloundecapeptide cyclosporin A (CsA) was first isolated from the insect-pathogenic fungus Tolypocladium inflatum for its antifungal activity and later developed as an immunosuppressant drug. However, the full biosynthetic mechanism of CsA remains unknown and has puzzled researchers for decades. In this study, the biosynthetic gene cluster is suggested to...

Resource Type:

Article

Full Text:

Benefits Fungal Adaptation to the Environment Xiuqing Yang,a,b Peng Feng,a Ying Yin,a Kathryn Bushley,c
Genome-Wide Characterization of Light-Regulated Genes in Neurospora crassa

Creator:

Wu, Cheng, Yang, Fei, Smith, Kristina M., Peterson, Matthew, Dekhang, Rigzin, Zhang, Ying, Zucker, Jeremy, Bredeweg, Erin L., Mallappa, Chandrashekara, Zhou, Xiaoying, Lyubetskaya, Anna, Townsend, Jeffrey P., Galagan, James E., Freitag, Michael, Dunlap, Jay C., Bell-Pedersen, Deborah, and Sachs, Matthew S.

Abstract:

The filamentous fungus Neurospora crassa responds to light in complex ways. To thoroughly study the transcriptional response of this organism to light, RNA-seq was used to analyze capped and polyadenylated mRNA prepared from mycelium grown for 24 hr in the dark and then exposed to light for 0 (control) 15,...

Resource Type:

Article