Non-steroidal anti-inflammatory drugs (NSAIDs) are used to control pain and inflammation, but can have serious adverse effects, including gastrointestinal ulceration. Non-selective NSAIDs inhibit both cyclooxygenase isoforms: COX-1 and COX-2. COX-2 is primarily responsible for the inflammatory response, while COX-1 is constitutively expressed, representing the dominant source of prostaglandins for gastric...
Canine transitional cell carcinoma (TCC) has been shown to have a substantial inflammatory component. It exhibits genotypic and morphologic elements that resemble its human counterpart. Cyclooxygenases (COX) are key enzymes in the synthesis of proinflammatory molecules, such as prostaglandins. Excess prostaglandin production through cyclooxygenases may promote oncogenesis and progression of...
Egg fat is of considerable importance in the nutrition of the developing chick as a source of energy and essential fatty acids such as linoleic (18:2 n-6) and α-linolenic (18:3 n-3) acids. During incubation, yolk lipids provide fatty acids that are utilized for energy, synthesis of polyunsaturated fatty acids (PUFA)-rich...
An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is...
Foot pathology is a real problem in captive elephants. Osteoarthritis is the major concern among musculoskeletal disorders and foot health problems for elephants in North America zoos with one-‐half of Elephants in captivity showing foot health care problems in zoos. A higher ratio of captive Asian elephants (Elephas maximus) is...
Two experiments were conducted looking at both acute and sub-acute laminitis. An acute nutritional induction model was used to examine whether blood profiles and gene expression are similar to other studies conducted using an endotoxin induction model. Twelve sheep were randomly assigned to three treatment groups which were control, 4-hour...
In the presence of internal or external stressors, the body requires sources of energy that aide cells to combat inflammation. Fatty acids are an important source of energy and are vital components of cell membranes. Dietary fatty acids (n-6 and n-3) are of importance in immune function because they are...
Three experiments evaluated the effects of different management strategies on immune function and performance of feeder cattle. The objective of experiment 1 was to compare the effects of anticipating, delaying, or vaccinating against Bovine Respiratory Disease (BRD) at the time of weaning and feedlot entry on growth, DMI, and plasma...
Feeding conjugated linoleic acids (CLA) improves reproductive performance in dairy cows; however, the molecular mechanisms by which CLA improves reproduction are not well understood. Therefore, we evaluated whether the CLA isomers, trans-10, cis-12 CLA and cis-9, trans-11 CLA altered synthesis of steroidogenic hormones in bovine luteal cells by measuring concentrations...
The purpose of this study was to investigate whether
the beneficial effects which the consumption of fish oil
imparts on hemostatic function can be modified by the level
of dietary selenium. Male Sprague Dawley rats were fed for
eight weeks semipurified diets containing 7% corn oil (by
weight) or 5.5%...