Aquatic animals are exposed to a variety of natural and
anthropogenic xenobiotics. Biotransformation of xenobiotics was
examined in three aquatic animals: a primitive mollusc (chiton);
a shellfish which is an important human food source (oyster);
and, a lower vertebrate model for toxicological studies (rainbow
trout). Since digestive glands of Cryntochiton...
Pacific walrus (Odobenus rosmarus) are particularly vulnerable to the impacts of climate change due to the high reliance on sea ice for safety, transport, and social behaviors. Additionally, the walrus diet consists of predominantly bivalves, whose populations are in decline as a result of ocean acidification. We first determined the...
Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
There is increased emphasis on understanding cumulative risk from the combined effects of chemical and non-chemical stressors as it relates to public health. Recent animal studies have identified pulmonary inflammation as a possible modifier and risk factor for chemical toxicity in the lung after exposure to inhaled pollutants; however, little...
The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
Senecio jacobaea (tansy ragwort) is a common weed in the
Pacific Northwest that contains toxic pyrrolizidine alkaloids
(PAs). Jacobine, the major PA in Senecio jacobaea, was incubated
with rat liver microsomes and metabolites were isolated by high
performance liquid chromatography (HPLC) and identified by mass
spectrometric analysis. Metabolites included a...
We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
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regarding the responses to various environmental pulmonarytoxicants by 27% of African Americans and 5% of
We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
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environmental pulmonarytoxicants. Researchers recently reported finding high levels of Fmo1, and low levels of
The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of lowdose environmental mixtures and carcinogens in the promotion of invasion and metastasis...
The effects of L-ascorbic acid, thiamine HC1, or L-cysteine on
acetaldehyde blood levels and disposition were investigated in acetaldehyde-
treated rats. Rats were treated with ascorbic acid (2
mmoles/kg), thiamine (0.24 mmole/kg), or cysteine (2 mmoles/kg) one
hour before the administration of acetaldehyde (6 mmoles/kg). The
results show that each...