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Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor

Creator:: Vogel, Walter Kevin
Resource Type:: Dissertation
Full Text:: Site-Directed Mutagenesis of the m2 Muscarinic Acetylcholine

Impacts of Tertiary Ligands in Catalysis in Thermostable Human Carbonic Anhydrase II by Site-directed Mutagenesis and Genetic Code Expansion

Creator:: Stevens, Danielle M.
Abstract:: Carbonic anhydrases are ubiquitous enzymes that catalyze the reverse hydration and dehydration of carbon dioxide and bicarbonate respectively. A variety of tumors in humans show overexpression of human carbonic anhydrase II (HCA II) leading to an acidic breakdown of carbon dioxide into bicarbonate. While a variety of drug inhibitors exist,...
Resource Type:: Research Paper
Full Text:: Thermostable Human Carbonic Anhydrase II by Site-directed Mutagenesis and Genetic Code Expansion Danielle

Site-directed mutagenesis of chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) in different functional domain

Creator:: Wang, Zhaohong
Resource Type:: Masters Thesis
Full Text:: Site-directed mutagenesis of chicken ovalbumin upstream

Muscarinic receptor-effector coupling in Chinese hamster ovary cells

Creator:: Bulseco, Dylan A.
Resource Type:: Dissertation
Full Text:: Chinese Hamster Ovary Cells. Abstract approved: Michael I. Schimerlik Site-directed mutagenesis was

Factors contributing to the formation of CC-->TT tandem mutations

Creator:: Skinner, Amy M.
Abstract:: The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Resource Type:: Dissertation
Full Text:: resolute that I take his DNA Repair and Mutagenesis course because much of the literature from that

Biochemical characterization and mutational analysis of human uracil-DNA glycosylase

Creator:: Chen, Cheng-Yao
Abstract:: PCR-based codon-specific random mutagenesis and site-specific mutagenesis were performed to construct a library of 18 amino acid changes at Arg276 in the conserved leucine-loop of the core catalytic domain of human uracil-DNA glycosylase (UNG). Each Arg276 mutant was then overproduced in E. coli cells and purified to apparent homogeneity by...
Resource Type:: Dissertation
Full Text:: ........................................................................................ 93 2.2.9 Random and Site-directed Mutagenesis of Core Catalytic Domain of Human Uracil-DNA

Spontaneous and enviornmental [sic] mutagenesis in mismatch repair deficient cells

Creator:: Shin-Darlak, Chi Y.
Abstract:: DNA damage, if not repaired, can become a mutation. Mutation accumulation is associated with initiation and progression of tumorigenesis. DNA mismatch repair (MMR) is required for maintaining genetic stability by repairing replication errors. Biochemical studies have shown that MMR also recognizes mismatch-causing DNA lesions, suggesting the role of MMR in...
Resource Type:: Dissertation
Full Text:: Environmental Mutagenesis in Mismatch Repair Deficient Cells Abstract approved: Mitchell S. Turker DNA damage

Deoxyguanosine triphosphate, a possible target for reactive oxygen species-induced mutagenesis

Creator:: Tassotto, Mary Lynn Benka
Abstract:: Intracellular dNTP pool sizes are highly asymmetric, with dGTP usually comprising 5 to 10% of the sum of the dNTP pools. The work presented in this dissertation addresses the question of whether the underrepresentation of dGTP is related to its potential to be oxidized by reactive oxygen species. 8-oxo-guanine is...
Resource Type:: Dissertation
Full Text:: . Title: Deoxyguanosine Triphosphate. a Possible Target for Reactive Oxygen Species- Induced Mutagenesis

Mutagenic mechanisms associated with DNA cytosine methylation, DNA base sequence context and DNA precursor pool asymmetry

Creator:: Zhang, Xiaolin
Resource Type:: Dissertation
Full Text:: factor relating DNA-cytosine methylation to spontaneous mutagenesis. A major source of spontaneous

Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites

Creator:: Knight, Eva W.
Abstract:: Myxobacteria represent an interesting class of Gram-negative soil bacteria. These bacteria utilize organic materials from the environment as a food source by the action of their extracellular hydrolytic enzymes. They grow vegetatively in the presence of adequate nutrients. During starvation conditions, however, they aggregate and form multicellular structures called fruiting...
Resource Type:: Masters Thesis
Full Text:: , site-directed mutagenesis techniques were also employed in studying the domain flexibility and

ScholarsArchive@OSU

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor

Impacts of Tertiary Ligands in Catalysis in Thermostable Human Carbonic Anhydrase II by Site-directed Mutagenesis and Genetic Code Expansion

Site-directed mutagenesis of chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) in different functional domain

Muscarinic receptor-effector coupling in Chinese hamster ovary cells

Factors contributing to the formation of CC-->TT tandem mutations

Biochemical characterization and mutational analysis of human uracil-DNA glycosylase

Spontaneous and enviornmental [sic] mutagenesis in mismatch repair deficient cells

Deoxyguanosine triphosphate, a possible target for reactive oxygen species-induced mutagenesis

Mutagenic mechanisms associated with DNA cytosine methylation, DNA base sequence context and DNA precursor pool asymmetry

Biosynthesis studies and mutasynthesis of myxobacterial secondary metabolites

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