Sporadic canine colorectal cancers (CRCs) should make excellent models for studying the corresponding human cancers. To molecularly characterize canine CRC, we investigated exonic sequence mutations of adenomatous polyposis coli (APC), the best known tumor suppressor gene of human CRC, in 23 sporadic canine colorectal tumors, including 8 adenomas and 15...
In part one, levels of dehydrated alfalfa meal greater than 60% of the diet significantly (P < 0.01) reduced the growth of rats fed isocaloric diets. Purified cellulose fed to provide the same amount of acid detergent fiber as contributed by the alfalfa did not affect growth. Feed intake was...
The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
To reduce the loss of feeding calves during the nursing period
and to conserve milk for human consumption research has been conducted
to develop milk replacer formulas which result in calf performance
comparable to that of milk. In the first section of this investigation
different aspects of utilization of fats,...
In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...
Although much is known about the effects of electroshock on fish physiology, consequences to the immune system and disease progression have not received attention. Our objectives were to determine the effects of electroshock on selected immune function in juvenile spring chinook salmon Oncorhynchus tshawytscha, the mechanism of any observed alteration,...
Production of fresh produce takes place outdoors, and therefore, is exposed to many routes of contamination (e.g., soil, contaminated water, manure, etc.) by human pathogens. Although precautions are taken to reduce this risk, pathogens can be regularly introduced to produce handling facilities. To manage the risk of cross-contamination from potentially...
Plasma concentrations of cortisol, a glucocorticoid hormone that
is immunosuppressive in mammals, increase during stress and
smoltification of salmonids. There was a reduction in the ability of
lymphocytes to generate antibody producing cells (APC) in vivo
concurrent with increased plasma cortisol titers during smoltification
of coho salmon (Oncorhvnchus kisutch). Cortisol...
The consumption of seafood in the United States has increased rapidly in recent years due to high quality protein and health benefits of seafood. Seafood can be a carrier for bacteria normally distributed in the marine environment and, in some cases, can be contaminated by human pathogens. Therefore, there is...
Electrofishing is a sampling tool commonly used by fisheries researchers. While much is known about the effects of electroshock on fish physiology, consequences to the immune system and disease progression have not received attention. To understand the effects of electroshock on immune function we undertook a comparison of electroshock and...