We compared estimates of bacterial abundance and of average bacterial cell size based on direct counts of bacterioplankton cells stained with acridine orange (AO) or 4’-6-diamidino-2-phenylidole (DAPI). Estimates of numbers mll–1 of bacteria stained with DAPI were on average 70% (range 57–82%) of bacterial counts made with AO as the...
Neste estudo exploratório, de caráter qualitativo, objetivamos compreender a experiência de adolescentes em museus de ciência em visita fora do contexto escolar. Em particular, apresentamos a análise da visita de cinco grupos, entre 14 e 17 anos, de escolas públicas, à exposição “Passado e Presente - ciência, saúde e vida...
An active object system is a transition-based object-oriented system suitable for the design of various concurrent systems. An AOS consists of a collection of interacting objects, where the behavior of each object is determined by the transition statements provided in the class of that object. A transition statement is a...
This paper addresses cost-sensitive classification in the setting where there are costs for measuring each attribute as well as costs for misclassification errors. We show how to formulate this as a Markov Decision Process in which the transition model is learned from the training data. Specifically we assume a set...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Full Text:
oligonucleotide
(AO)-mediated exon-skipping therapeutics is promising for
DMD patients based on encouraging
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Despite the advances in surgery, physical therapy, and pharmaceutical agents, muscle
dysfunction (i.e., atrophy and weakness) continues to impair recovery from an anterior
cruciate ligament (ACL) injury and surgery. Ischemia-reperfusion injury during surgery
and the subsequent limb disuse are two events experienced by patients having ACL
surgery. Oxidative stress and...
The effect of a 9—month nutrition education and walking program on
energy need, body composition, nutrient intake, nutritional status,
aerobic fitness, and health risk factors was determined in 7 women with
childhood—onset obesity (CO) and 8 women with adult—onset obesity (AO).
Data were collected before and after the 9—month program...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...