N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Full Text:
GluN2B. GluN2A (amino acids 875-1029) was fused to GST and used as a bait to
identify proteins from
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Full Text:
calmodulin.
Titration of (A) GluN2A (991-1029) or (B) GluN1-C0 (834-864) quenched Alexa-488-labeled
N-methyl-D-aspartate (NMDA) receptors are calcium-permeable ion channels
assembled from four subunits that each have a common membrane topology. The
intracellular carboxyl terminal domain (CTD) of each subunit varies in length, is least
conserved between subunits, and binds multiple intracellular proteins. We defined a
region of interest in the GluN2A CTD,...
Many centers of population in the Pacific Northwest are dependent
upon employment in the forest based industries. Mary of these
timber dependent communities look to the public forests for their raw
wood requirements. In some localities the installed capacity has outstripped
the local wood supply. This necessitates reaching into other...
EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Outcrops of old strata at the shelf edge resulting from erosive gravity‐driven flows
have been globally described on continental margins. The reexposure of old strata allows
for the reintroduction of aged organic carbon (OC), sequestered in marine sediments for
thousands of years, into the modern carbon cycle. This pool of...
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These first measurements of specific surface area (SSA)
of bulk samples of subsurface marine basalts were undertaken
to determine the potential area available for microbial
colonization. SSA ranged from 0.3 to 52 m2/g of basalt
with the lowest value coming from pillow basalt and the
highest value from breccia. The...
Siletzia is a basaltic Paleocene and Eocene
large igneous province in coastal Oregon,
Washington, and southern Vancouver Island
that was accreted to North America in the
early Eocene. New U-Pb magmatic, detrital
zircon, and ⁴⁰Ar/³⁹Ar ages constrained by
detailed field mapping, global nannoplankton
zones, and magnetic polarities allow correlation
of...