Index Catalog // ScholarsArchive@OSU

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

Creator:: Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Lam, Siew Hong, Mathavan, Sinnakaruppan, Parinov, Serguei, and Gong, Zhiyuan
Abstract:: Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein in hepatocarcinogenesis remains elusive. In this...
Resource Type:: Article
Full Text:: oncogenic krasV12 specifically in the transgenic zebrafish liver. Only a high level of krasV12 expression

An inducible kras[superscript v]¹² transgenic zebrafish model for liver tumorigenesis and chemical drug screening

Creator:: Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Parinov, Serguei, and Gong, Zhiyuan
Abstract:: Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the kras(V12) oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation between zebrafish and human liver tumorigenesis, the low tumor incidence and early mortality...
Resource Type:: Article
Full Text:: . and Gong, Z. (2011). A high level of liver-specific expression of oncogenic KrasV12 drives robust

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors

Creator:: Li, Zhen, Zheng, Weiling, Wang, Zhengyuan, Zeng, Zhiqiang, Zhan, Huiqing, Li, Caixia, Zhou, Li, Yan, Chuan, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Myc is a pleiotropic transcription factor that is involved in many cellular activities relevant to carcinogenesis, including hepatocarcinogenesis. The zebrafish has been increasingly used to model human diseases and it is particularly valuable in helping to identify common and conserved molecular mechanisms in vertebrates. Here we generated a liver tumor...
Resource Type:: Article
Full Text:: high level of liver-specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Creator:: Evason, Kimberley J., Francisco, Macrina T., Juric, Vladislava, Balakrishnan, Sanjeev, del Pilar Lopez Pazmino, Maria, Gordan, John D., Kakar, Sanjay, Spitsbergen, Jan, Goga, Andrei, and Stainier, Didier Y. R.
Abstract:: Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-catenin. To...
Resource Type:: Article
Full Text:: Liver Tumorigenesis in Zebrafish Identification of Chemical Inhibitors of β-Catenin-Driven Liver

NguyenAnhMicrobioDevelopmentConditionalLiver.pdf

Creator:: Nguyen, Anh Tuan, Koh, Vivien, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Here we report a new transgenic expression system by combination of liver-specific expression, mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure of mifepristone to induce permanent genomic recombination mediated by...
Full Text:: . et al. A high level of liver-specific expression of oncogenic Kras(V12) drives robust liver

SpitsbergenJanMicrobiologyCrosstalkRasRho.pdf

Creator:: Chew, Ti Weng, Liu, Xing Jun, Liu, Lihui, Spitsbergen, Jan M., Gong, Zhiyuan, and Low, Boon Chuan
Abstract:: RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell growth and tissue development through their distinct signaling pathways. While much has been learnt about their individual functions in both cell and animal models, the physiological and pathophysiological consequences of their signaling crosstalk in multi-cellular context...
Full Text:: -specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in transgenic zebrafish. Dis

SpitsbergenJanMicrobiologyOncogenicKRASPromotes.pdf

Creator:: Ju, Bensheng, Chen, Wenbiao, Orr, Brent A., Spitsbergen, Jan M., Jia, Sujuan, Eden, Christopher J., Henson, Hannah E., and Taylor, Michael R.
Abstract:: BACKGROUND: Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic value. However, they are just emerging as a model for human brain tumors, which are among the most...
Full Text:: , Spitsbergen JM, Lam SH, Mathavan S, et al. A high level of liver-specific expression of oncogenic Kras(V12

SpitsbergenJanMicrobiologyMyc-InducedLiver.pdf

Creator:: Sun, Lili, Anh Tuan Nguyen, Spitsbergen, Jan M., and Gong, Zhiyuan
Abstract:: Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Full Text:: inducible kras(V12) transgenic zebrafish model for liver tumorigenesis and chemical drug screening. Dis

Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Creator:: Koch, Daniel C.
Abstract:: The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of the basic helix-loop-helix Per/ARNT/Sim (bHLH/PAS) family of chemosensors and developmental regulators. As a member of the PAS domain family of transcription factors responsive to exogenous signals, the AhR exerts influence on many processes relating to cellular fate....
Resource Type:: Dissertation
Full Text:: cells exhibit high expression of AhR, which can be activated by AhR ligands present in cruciferous

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

Creator:: Garland, Michael A.
Abstract:: Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
Resource Type:: Dissertation
Full Text:: on the differential expression of miRNAs during zebrafish fin regeneration demonstrated robust fold

ScholarsArchive@OSU

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

An inducible kras[superscript v]¹² transgenic zebrafish model for liver tumorigenesis and chemical drug screening

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

NguyenAnhMicrobioDevelopmentConditionalLiver.pdf

SpitsbergenJanMicrobiologyCrosstalkRasRho.pdf

SpitsbergenJanMicrobiologyOncogenicKRASPromotes.pdf

SpitsbergenJanMicrobiologyMyc-InducedLiver.pdf

Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Transcriptomic approaches for discovering regenerative and developmental regulatory networks in zebrafish

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