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  • Biosynthesis and Rational Design of Novel Pactamycin Analogs

    Creator:
    Abugrain, Mostafa E.
    Abstract:
    Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
    Resource Type:
    Dissertation
    Full Text:
    Microsoft Word - Mostafa E. Abugrain 2015.docx

  • Exploring Pactamycin Biosynthesis

    Creator:
    Roland, Jessica
    Abstract:
    Pactamycin, produced by the soil bacterium Streptomyces pactum, is a cytotoxic antibiotic that belongs to the aminocyclitol family of natural products. This antibiotic has shown various forms of biological activity, including antibacterial, antifungal, antimalarial, and antitumor activities. Despite its outstanding biological activity, the mode of formation of its pharmacophore (the...
    Resource Type:
    Honors College Thesis
    Full Text:
    student Dr. Mostafa Abugrain for consistently answering my questions about research and for teaching me

  • Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

    Creator:
    Eida, Auday
    Abstract:
    Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
    Resource Type:
    Dissertation

  • Exploring the Synthesis of 4-Deoxygadusol

    Creator:
    Jujjuri, Anantha Poojitha
    Abstract:
    Sunscreen products are used worldwide to protect the skin from ultraviolet radiation. However, some of the ingredients used in sunscreen products are fatal to coral reefs especially in areas where tourism is a large part of the economy. In this study, we explored a synthetic route to produce 4-deoxygadusol, which...
    Resource Type:
    Honors College Thesis
    Full Text:
    , Hattan Alharbi, Auday Eida, Abdullah Alanzi, Mostafa Abugrain, Andrew Osborn, Ananiya Demessie, and

  • Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

    Creator:
    Brumsted, Corey J.
    Abstract:
    Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
    Resource Type:
    Dissertation
    Full Text:
    Chapter 2. Akane Hirayama (Kudo and Eguchi Lab) and Mostafa Abugrain (Mahmud lab) performed the genetic

  • Regulation of Secondary Metabolite Production in Streptomyces

    Creator:
    Abdullah, Alanzi R.
    Abstract:
    Among the myriad of natural products are pseudosugar-containing secondary metabolites, e.g., the C7-pseudosugar-containing oligosaccharide acarbose, the C6- pseudosugar-containing aminoglycoside antibiotics, and the five-membered ring pseudosugar-containing antibiotic pactamycin. The C7-pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called sedoheptulose 7-phosphate cyclases (SH7PCs). This family of enzymes...
    Resource Type:
    Dissertation
    Full Text:
    support of my fellow labmates, Dr. Mostafa Abugrain, Dr. Yosi Nindita, Auday Eida and Hattan Alharbi

  • Development of Novel Agents to Combat Tuberculosis and Malaria

    Creator:
    Almabruk, Khaled Husain G.
    Abstract:
    Despite the advance of biomedical science, infectious diseases remain one of the number one killers in the world. They claim the lives of millions of people annually, particularly in underdeveloped and developing countries. In fact, more than 32% of the health burden in Africa is caused by infectious diseases, e.g.,...
    Resource Type:
    Dissertation
    Full Text:
    contributions of all authors. In Chapter 4, Drs. Wanli Lu and Mostafa Abugrain prepared and characterized the

  • Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

    Creator:
    Abuelizz, Hatem A.
    Abstract:
    This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
    Resource Type:
    Dissertation
    Full Text:
    my studies specially Mostafa Abugrain. TABLE OF CONTENTS Page

  • Ecosystem Processes in Treated and Untreated Western Juniper Systems in Semiarid Watersheds: A Paired Watershed Study in Central Oregon

    Creator:
    Abdallah, Mohamed AB.
    Abstract:
    Western juniper (Juniperus occidentalis) encroachment has been associated with negative ecological and hydrological consequences including reductions in herbaceous production and diversity, deterioration for wildlife habitat, and higher erosion and runoff potentials. As a result, western juniper removal is a common and accepted rangeland management practice. Although studies evaluating the ecological...
    Resource Type:
    Dissertation
    Full Text:
    , Abdurrahman Elmaghbub, Adam Zaid, Ibrahem Elayeb, Essdik Habashi, Ali Mohamed, Ahmed Elomami, Mostafa

  • Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

    Creator:
    Osborn, Andrew
    Abstract:
    Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
    Resource Type:
    Dissertation
    Full Text:
    members of the Taifo Mahmud laboratory, specifically Dr. Corey Brumsted, Dr. Mostafa Abugrain, and Dr