Using combined HPLC-RIA, cytokinin levels in a series of tobacco crown gall tumors, having altered morphologies as a result of transposon mutagenesis were examined. Average trans-ribosylzeatin levels in the shoot-producing tumors (tms mutants) and root-producing tumors (tmr mutants) were 1400 pmol/gm and 0.97 pmol/gm, respectively. Cytokinin/auxin ratios were highest in...
The Northwest Archivists (NWA), a regional archival association in the Pacific Northwest, established a formal mentoring program in 2007. A pilot phase of the program ran for 2 years and included both formative and summative assessments from participants. This case study documents NWA’s experiences designing and managing a mentoring program...
A novel swine-origin H1N1 influenza A virus has been identified as the cause of the 2009 influenza pandemic in humans. Since then, infections with the pandemic (H1N1) 2009 influenza virus have been documented in a number of animal species. The first known cases of lethal respiratory disease associated with pandemic...
A novel swine-origin H1N1 influenza A virus has been identified as the cause of the 2009 influenza pandemic in humans. Since then, infections with the pandemic (H1N1) 2009 influenza virus have been documented in a number of animal species. The first known cases of lethal respiratory disease associated with pandemic...
Full Text:
Due to
Pandemic (H1N1) 2009 Influenza A Virus
Christiane V. Löhr, Emilio E. DeBess, Rocky J
A novel swine-origin H1N1 influenza A virus has been identified as the cause of the 2009 influenza pandemic in humans. Since then, infections with the pandemic (H1N1) 2009 influenza virus have been documented in a number of animal species. The first known cases of lethal respiratory disease associated with pandemic...
The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of
senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted
melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and
ribonucleotide...
In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response (DDR). Oxidative stress and hyper-replication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here we report that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage in...