The effects of L-ascorbic acid, thiamine HC1, or L-cysteine on
acetaldehyde blood levels and disposition were investigated in acetaldehyde-
treated rats. Rats were treated with ascorbic acid (2
mmoles/kg), thiamine (0.24 mmole/kg), or cysteine (2 mmoles/kg) one
hour before the administration of acetaldehyde (6 mmoles/kg). The
results show that each...
Enantioselective epoxidation of crotyl alcohol, followed
by a cuprate mediated methylation, gave a 1:1 mixture of
(2S) -3- methyl -1,2- butanediol and (2R,3S)-2-methy1-1,3-
butanediol. The latter was separated as its 2,4,6-trimethylbenzenesulfonate
derivative and converted via the
iodide to the corresponding phosphonium salt. The separated
butanediol derivatives were independently transformed
to...
Ethanol caused altered mobility of the lipophylic probe,
1,6-diphenyl-1,3,5-hexatriene in plasma membrane preparations of
Saccharomyces cerevisiae. Because lipids had been shown to protect
yeast against ethanol toxicity, sterols, fatty acids, proteins, and
combinations of these were tested, but protection from growth
inhibition was not seen. Ethanol-induced prolonged lag periods and...
1-(2-pyridyl)-3-methyl-3-butene-2-ol was prepared by allowing 2-picolyllithium to react with methacrolein.
In the reaction of picolyllithium with crotonaldehyde, two products 1-(2-pyridyl)-4-methyl-3-butene-2-ol and 1-(2-pyridyl)-4-methyl-2-butene-4-ol were formed.
1-(2-pyridyl)-3-methyl-3-butene-2-ol was subjected to the low
pressure hydrogenation, using methanol as solvent and PtO₂ as catalyst. A red yellow liquid 1-(2-pyridyl)-3-methyl-2-butanol was
obtained. Derivatives of the...
The question of why carboxylic acids and phenols are stronger
acids than alcohols has been investigated experimentally and theoretically.
The experimental approach involves comparison of gas-phase
acidities and core-ionization energies. The theoretical treatment uses
calculated point potentials and acidities.
The ease of proton removal is related to two factors known...
A sample of 1,003 women, age 22 in 1983-84 and age 27 in 1988-89, were
selected from the National Longitudinal Survey of Youth. Personal, familial, and
geopolitical predictors of alcohol consumption were evaluated at each time period and
longitudinally. The study integrated macro- and micro-level influences to determine
their influence...