Currently, the two most critical factors of microprocessor design are performance and power. The optimum balance of these two factors is reflected in the speed-power product(SPP). 32-bit CMOS adders are used as representative circuits to investigate a method of
reducing the SPP. The purpose of this thesis is to show...
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants generated as byproducts of natural and anthropogenic combustion processes. Despite significant public health concern, physiologically based pharmacokinetic (PBPK) modeling efforts for PAHs have so far been limited to naphthalene, plus simpler PK models for pyrene, nitropyrene, and benzo[a]pyrene (B[a]P). The dearth of...
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
Growing awareness and concern within society over the use of and reliance on fossil fuels has stimulated research efforts in identifying, developing, and selecting alternative energy sources and energy technologies. Bioenergy represents a promising replacement for conventional energy, due to reduced environmental impacts and broad applicability. Sustainable energy challenges, however,...
The main goal of automated test generation is to improve the reliability of a program by exposing faults to developers. To this end, testing should cover the largest possible portion of the program given a test budget (i.e., time and resources) as frequently as possible. Coverage of a program entity...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:
, Kristopher W. Krausz1, Jingmin Shi1, Chad N. Brocker1,
Dhimant Desai4, ShantuG. Amin4, William H. Bisson5
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we
show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling
exclusively in intestine, and improves metabolic parameters in mouse models of obesity.
Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:
mice.
(f, g) Glucose tolerance test (f) and the area under the curve (AUC) (g) in vehicle- and Gly-MCA
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
The purpose of this thesis is to represent and calculate unsymmetrical
secondary faults on a grounded wye-to-delta transformer
bank.
This thesis is specifically concerned with the secondary connections
often encountered in industrial installations. Faults on these
systems have not been adequately investigated.
Three types of faults are considered, namely:
1....