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Development of mucosal vaccines for avian influenza A virus composed of recombinant Lactococcus lactis and Streptococcus gordonii

Creator:

Reese, Kaleb A.

Abstract:

Novel mucosal vaccines (LL-M2e, LL-HAe, SG-HAe) were constructed from live, non-pathogenic Lactococcus lactis or Streptococcus gordonii that express conserved regions of HA or M2 antigens from avian influenza virus (AIV) A. All three vaccines evoked antigen-specific serum immunoglobulin G (IgG) responses in vaccinated chickens. The addition of the adjuvant cholera...

Resource Type:

Masters Thesis

Full Text:

Mucosal Vaccines for Avian Influenza A Virus Composed of Recombinant Lactococcus lactis and
Targeted development of antivirals against influenza A and respiratory syncytial virus

Creator:

Lupfer, Christopher

Abstract:

Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand RNA viruses which infect the respiratory mucosa of animals and humans. Despite decades of research and development of antivirals and vaccines, both of these viruses continue to be a major health concern throughout the world. The focus of...

Resource Type:

Dissertation

Full Text:

Development of Antivirals against Influenza A and Respiratory Syncytial Virus. Abstract approved