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  • Employing Genetic Code Expansion Tools to Elucidate Disease Mechanisms and Generate New Therapeutics

    Creator:
    Van Fossen, Elise M.
    Abstract:
    In biology, function and disease are closely intertwined, requiring the coordination of hundreds of intricate chemical reactions. Interdisciplinary cooperation between chemical and biological approaches is necessary to decipher the chemical links between physiological and pathological conditions. In this arena, the precision tools made possible with chemical biology can manipulate and...
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    performed experiments and wrote the paper. Joseph Beckman planned experiments. P. Andrew Karplus and

  • Electron diffraction of molecules in superfluid helium droplets

    Creator:
    He, Yunteng
    Abstract:
    In this dissertation, I describe the experimental investigation in electron diffraction of molecules in superfluid helium droplets. The project is part of an overall scheme called ‘single molecule serial electron diffraction imaging’ (SS-EDI), with the ultimate goal of building an apparatus to determine atomic structures from oriented macromolecules. In SS-EDI,...
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    Dissertation
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    my thesis committee: Dr. Joseph Beckman, Dr. Valery Voinov, Dr. Michelle Dolgos and Dr. John

  • Vitamin E and the alpha-tocopherol transfer protein during zebrafish embryogenesis

    Creator:
    Miller, Galen W.
    Abstract:
    Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
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    Dissertation
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    -set, something I hope to emulate. Dr. Joe Beckman was almost a third advisor to me through my years

  • Calpain 2 proteolysis regulates glioblastoma cell invasion

    Creator:
    Lal, Sangeet Kumar
    Abstract:
    Glioblastoma is the most malignant primary brain tumor with the average patients surviving only one year after diagnosis, even with aggressive therapy. The formation of numerous micro-tumors dispersed into the brain due to rapid invasion of tumor cells, presents the primary challenge to the surgical removal of tumors and limits...
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    discussions with my thesis committee members, Joseph Beckman, Michael Freitag, John Fowler and Jean Hall

  • Modeling protein structure at atomic resolution

    Creator:
    Berkholz, Donald S.
    Abstract:
    This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...
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    Dissertation
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    AN ABSTRACT OF THE DISSERTATION OF Donald S. Berkholz for the

  • Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

    Creator:
    Gómez Ramirez, Luis A.
    Abstract:
    Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...
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    research committee, Drs. Claudia S. Maier, Balz Frei, Joseph Beckman and Adam Higgins not only for

  • Metabolism of one carbon (C1) and methylated compounds in SAR11 bacteria

    Creator:
    Sun, Jing
    Abstract:
    SAR11 Alphaproteobacteria are the most abundant aerobic chemoheterotrophs in ocean surface waters. Previous studies have indicated SAR11 cells play an important role in marine carbon cycling and consume up to half of some common dissolved organic compounds, such as amino acids. During sequencing of the first SAR11 genome, genes for...
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    Dissertation
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    would also like to thank my supervisory committee members, Dr. Daniel D. Rockey, Dr. Joseph S. Beckman

  • Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

    Creator:
    Knecht, Andrea L.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
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    : Dr. Joe Beckman, Dr. Kim Anderson, Dr. Siva Kolluri, and Dr. Susan Tilton. The members of the

  • Functional, structural and evolutionary analyses of the ferritin-like superfamily of proteins

    Creator:
    Cooley, Richard Bleier
    Abstract:
    The ferritin-like superfamily (FLSF) of proteins is composed of a wide variety of functionally diverse proteins involved in oxygen dependent metal-mediated electron transfer reactions. Their biological importance is exemplified by the fact FLSF proteins are found in almost every organism from all three domains of life. Their functions range from...
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    other members my committee, Joe Beckman and Jerry Heidel, for your interest in my development as a

  • A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

    Creator:
    Monette, Jeffrey S.
    Abstract:
    Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
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    like to thank the members of my graduate committee, Drs. Balz Frei, Joseph Beckman, J. Fred Stevens