The immune system has been identified as a very sensitive target for the toxic effects of 2,3,7,S-tetrachlorodibenzo-p-dioxin (TCDD). Exposure to TCDD has been shown to disrupt the generation of both cell-mediated and humoral T cell-dependent immunity in laboratory animals; however, the mechanism remains unknown. In this dissertation, the hypothesis is...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
The reason for reading for pleasure falling out of popular fashion is ambiguous, and there is an ongoing drive to identify the source in order to encourage more reading. I attempted to see if liking the books assigned to one in middle and high school had an effect on reading...
A model of acute glutamate- and domoate-induced toxicity was developed and characterized in cultured rat cerebellar granule cells (CGCs) using experimental conditions which preserve the voltage-dependency of NMDA receptor function. Glutamate, which is normally non-toxic to CGCs in physiologic media (pH 7.4), was shown to induce a cytotoxic response after...
The purpose of this study was to determine whether women aged 65
and older are wearing sweatshirts and sweatpants for activewear, and, if so,
to investigate the types of activities they are worn for, reasons for wearing,
feature preferences, and fitting problems. While sweatshirts and sweatpants
have been popularly worn...
We develop an approach for measuring in-well fluid velocities using point electrical heating combined with spatially and temporally continuous temperature monitoring using distributed temperature sensing (DTS). The method uses a point heater to warm a discrete volume of water. The rate of advection of this plume, once the heating is...
With current nonlinear analysis computer capabilities, this
study was conducted to develop a linkage element that permits
analyses of wood composite structures taking into account possible
slip in the nailed joints. The finite elements chosen to represent the wood stud, plywood, gypsum and nails are described. The
method as applied...
Electrophoretic karyotypes were obtained from intact cells of four wild
type strains of Tilletia caries and T. controversa, and 5 inter specific hybrid
progeny using clamped homogeneous electric field, pulsed field gel
electrophoresis (CHEF PFGE). Each karyotype was polymorphic and unique
relative to the other strains. However, the relative size...