Search Constraints

Start Over
Filtering by: Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

Search Results

  • Revealing sequences and modifications of intact proteins using electron fragmentation

    Creator:
    Franklin, Rachel
    Abstract:
    People turn to mass spectrometry to answer some of life’s most important questions. From carbon dating of archeological finds to newborn blood screening tests, mass spectrometry allows us to measure molecules which helps advance our knowledge of life and the world we live in. One area of mass spectrometry that...
    Resource Type:
    Dissertation
    Full Text:
    Franklin for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on July 12, 2023

  • Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

    Creator:
    Estelle, Aidan B.
    Abstract:
    Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
    Resource Type:
    Dissertation
    Full Text:
    of Doctor of Philosophy in Biochemistry and Biophysics presented on September 13, 2022. Title

  • Strength in Numbers: How Multivalent WW-PPXY Interactions Regulate Cell Signaling

    Creator:
    Vogel, Amber J.
    Abstract:
    Cell signaling is often mediated by protein-protein interactions, which must be specific, tunable, and transient to allow agile responsiveness to cellular messages. Due to their unique properties, multivalent, intrinsically disordered proteins make ideal candidates to accomplish these vital tasks. A single protein with multiple binding sites may bind numerous partners,...
    Resource Type:
    Dissertation
    Full Text:
    for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on September 9, 2022

  • The Role of Cellular Senescence in the Development of Alzheimer's Disease

    Creator:
    Riordan, Ruben
    Abstract:
    Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
    Resource Type:
    Dissertation
    Full Text:
    THE DISSERTATION OF Ruben Riordan for the degree of Doctor of Philosophy in Biochemistry and

  • Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

    Creator:
    Padgitt-Cobb, Lillian K.
    Abstract:
    Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
    Resource Type:
    Dissertation
    Full Text:
    . Padgitt-Cobb for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on July 21

  • Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

    Creator:
    Fey, Rosalyn M.
    Abstract:
    Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
    Resource Type:
    Dissertation
    Full Text:
    . Fey for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on June 7, 2022

  • Context matters : assembly and disorder in the regulation of multivalent complexes

    Creator:
    Jara, Kayla A.
    Abstract:
    Intrinsically disordered proteins (IDPs), protein regions (IDRs), and protein complexes continue to emerge at the forefront of protein science. Proteins and protein regions lacking specific structure are found in all organisms, and often have vital roles in numerous biological processes. Breaking the well-known structure-function paradigm, the understanding of disorder-based functionality...
    Resource Type:
    Dissertation
    Full Text:
    . Jara for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on May 31, 2022

  • Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

    Creator:
    Otto, Shauna C.
    Abstract:
    Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
    Resource Type:
    Dissertation
    Full Text:
    the degree of Doctor of Philosophy in Biochemistry & Biophysics presented on March 8, 2022. Title

  • Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

    Creator:
    Baker, Kasie J.
    Abstract:
    The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
    Resource Type:
    Dissertation
    Full Text:
    THE DISSERTATION OF Kasie J. Baker for the degree of Doctor of Philosophy in Biochemistry and

  • Employing Genetic Code Expansion Tools to Elucidate Disease Mechanisms and Generate New Therapeutics

    Creator:
    Van Fossen, Elise M.
    Abstract:
    In biology, function and disease are closely intertwined, requiring the coordination of hundreds of intricate chemical reactions. Interdisciplinary cooperation between chemical and biological approaches is necessary to decipher the chemical links between physiological and pathological conditions. In this arena, the precision tools made possible with chemical biology can manipulate and...
    Resource Type:
    Dissertation
    Full Text:
    Biochemistry and Biophysics presented on December 3, 2021. Title: Employing Genetic Code Expansion