An in vitro labeling procedure was developed based
on optimal conditions of anticoagulant, stannous ion
concentration, incubation time, and incubation
temperature. This procedure was used to investigate the
effects of various agents on Tc-99m RBC labeling yields.
These agents were inorganic ions, therapeutic agents,
biochemicals, chelating agents, oxidizing agents, an...
This study lays the groundwork on potential techniques that could be employed to improve the post-thaw wash processing of cryopreserved human red blood cells. Transfusion of red blood cells is one of the most commonly practiced procedures in clinical medicine. Millions of red blood cell units are transfused to patients...
Cryoprotectants (CPAs) such as glycerol and dimethyl sulfoxide (DMSO) are commonly used during cryopreservation of cell based therapeutics. Although these additives are beneficial during freezing, it is often desirable to remove them before infusion into a patient. Currently, the most common method for CPA removal is by centrifugation. This method...