Developing new medical tests and identifying single biomarkers or panels of biomarkers with superior accuracy over existing classifiers promotes lifelong health of individuals and populations. Before a medical test can be routinely used in clinical practice, its accuracy within diseased and non-diseased populations must be rigorously evaluated. We introduce a...
Eliciting information from experts for use in constructing prior distributions for logistic regression coefficients can be challenging. The task is especially difficult when the model contains many predictor variables, because the expert is asked to provide summary information about the probability of “success” for many subgroups of the population. Often,...
BACKGROUND: Workers onboard freezer-trawl (FT) and freezer-longline (FL) vessels in Alaska may be at high risk for fatal and non-fatal injuries. METHODS: Traumatic occupational injuries onboard vessels in the FT and FL fleets were identified through two government data sources. RESULTS: The annual risk of fatal injuries was 125 per...
Primary injury prevention strategies are needed to improve worker safety in the fishing industry by reducing the occurrence of vessel disasters. In 2006, the United States Coast Guard (USCG) implemented a novel safety policy intervention for two fleets of freezer-trawlers and freezer-longliners in Alaska. The Alternate Compliance and Safety Agreement...
Emerging evidence suggests that the tumor microenvironment plays a critical role in regulating cancer
stem cells (CSCs) and tumor progression through both autocrine and paracrine signaling. Elevated
production of bone morphogenetic proteins (BMPs) from human ovarian cancer cells and stroma has
been shown to increase CSC proliferation and tumor growth....
The present studies investigated the cellular mechanisms for the detrimental effects of high dose whole body γ-irradiation on bone. In addition, radioadaptation and bone marrow transplantation were assessed as interventions to mitigate the skeletal complications of irradiation. Increased trabecular thickness and separation and reduced cancellous bone volume fraction, connectivity density,...