Index Catalog // ScholarsArchive@OSU

Creator:: Wagner, Katherine L.
Abstract:: Fanconi's Anemia (FA) is an autosomal recessive chromosomal instability disorder. The symptoms include congenital abnormalities, defective hematopoiesis (formation of cells of the blood), and high risk of developing acute myeloid leukemia and solid tumors. Fanconi researchers have long been puzzled by how Fanconi Anemia (FA) cells, which are known to...
Resource Type:: Honors College Thesis

Creator:: Gamble, John T.
Abstract:: The goal of this dissertation was to improve our abilities in acquiring critical in vivo data by establishing embryo-larva zebrafish as an exemplary model to quantitatively evaluate cancer progression. The living environment that encompasses a tumor has a significant effect on how cancer develops, grows and metastasizes. In order to...
Resource Type:: Dissertation
Full Text:: potential (Figure 1.2). Cancer cell proliferation can be prolific as malignant cells can quadruple in 3

Creator:: Harris, Krystal, L.
Abstract:: Background Bcl11b, previously CTIP2, is a zinc finger nuclear transcription factor involved in the development of keratinocytes, teeth, T lymphocytes, and nervous tissue. Expression of Bcl11b has been reported in human head and neck squamous cell carcinoma (HNSCC) and increased expression correlates with poorly differentiated tumors. This study aimed to...
Resource Type:: Masters Thesis
Full Text:: accumulate in the cell. P53 is the most commonly mutated gene in cancer; its loss of function allows cells

Creator:: Koch, Daniel C.
Abstract:: The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of the basic helix-loop-helix Per/ARNT/Sim (bHLH/PAS) family of chemosensors and developmental regulators. As a member of the PAS domain family of transcription factors responsive to exogenous signals, the AhR exerts influence on many processes relating to cellular fate....
Resource Type:: Dissertation
Full Text:: lead to cell cycle perturbation, and inhibit cellular growth. In A549 human lung cancer cells

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