Adverse effects of anti-epileptic (AED) medications on bone density have been reported since the 1960s. Phenytoin and carbamazepine, two commonly prescribed AED, are frequently associated with osteomalacia including fractures and reduced bone formation. The mechanism by which AED induces bone loss is not fully explained. We sought to determine the...
The effectiveness of three methods designed to inform
patients about digoxin side effects was evaluated. Subjects
were randomly assigned to receive information about their
digoxin by one of three treatment methods: (1) verbal
consultation alone, (2) A.S.H.P. printed leaflet, or
(3) both verbal consultation and leaflet. Treatments were
administered by...
The effect of oral contraceptives on urinary and plasma vitamin
B₆ as well as erythrocyte transaminase activities was investigated in
women. Five women who were taking oral contraceptives and four
who were not using these drugs served as subjects. They were
apparently healthy and free from any known metabolic disorder....
The effect of oral contraceptives on the urinary excretion of
several methionine metabolites was determined in women before and
after they had received a 3-g dose of L-methionine. Nine women
between the ages of 20-29 years served as subjects: five had been
using a combination-type oral contraceptive for six months...
Osteoporosis is a skeletal disease affecting 44 million Americans. A primary strategy to prevent osteoporosis is to develop a high peak bone mass in youth. Oral Contraceptives (OCs) alter hormones in women and could affect bone mass development. The interaction between OCs and skeletal mineralization is poorly understood. PURPOSE: Our...