The major purpose of this research was to characterize partially degraded proteins
appearing in the ocular lens during aging and cataract, and to identify the responsible
proteolytic activities. This research is significant, because increased protein
degradation is associated with lens opacification and cataract. Determining the sites
where lens proteins become...
Cataract is a leading cause of blindness throughout the world, yet the fundamental biochemical causes are unknown. A rodent model of the biochemical processes is selenite cataract. This cataract shows some of the features of human cataracts such as increased lens calcium, proteolysis of proteins, and insolubilization leading to lens...