Index Catalog // ScholarsArchive@OSU

Mitochondrial glutathione and the effect of perturbed calcium homeostasis on rat hepatocyte thiols

Creator:: Olafsdottir, Kristin
Abstract:: Recent studies have demonstrated that perturbations of intracellular thiol and calcium homeostasis may be important events in the early development of cell injury by toxic chemicals. Incubation of isolated rat hepatocytes in a calcium free medium, severely depleted intracellular Ca²⁺ levels and resulted in the loss of both cytosolic and...
Resource Type:: Dissertation
Full Text:: elucidation of the cellular processes involved in cell death are of vital importance to biology and medicine

Menage a trois : an evolutionary interplay between human papilloma virus, a tumor and a woman

Creator:: Shulzhenko, Natalia, Lyng, Heidi, Sanson, Gerdine F., and Morgun, Andrey
Abstract:: Cervical cancer is the third most common cancer in women with Human papillomavirus (HPV) being a key etiologic factor of this devastating disease. In this article, we describe modern advances in the genomics and transcriptomics of cervical cancer that led to uncovering the key gene drivers. We also introduce, herein,...
Resource Type:: Article
Full Text:: properties of cancers in sustaining proliferative signaling, resisting cell death, evading growth

Zebrafish models for translational neuroscience research: from tank to bedside

Creator:: Stewart, Adam Michael, Braubach, Oliver, Spitsbergen, Jan, Gerlai, Robert, and Kalueffl, Allan V.
Abstract:: The zebrafish (Danio rerio) is emerging as a new important species for studying brain mechanisms and its deficits. Focusing on selected CNS disorders (brain cancer, epilepsy and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience, and their contribution to neuroimaging, circuit-level and...
Resource Type:: Article
Full Text:: ), 264-278. doi:10.1016/j.tins.2014.02.011 10.1016/j.tins.2014.02.011 Elsevier/Cell Press Accepted

Use of γ-Glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial dysfunction, and cell death

Creator:: Will, Yvonne
Resource Type:: Dissertation
Full Text:: model to study the relationship between glutathione status, mitochondrial dysfunction, and cell death

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Creator:: Narayanan, Kannan Badri, Ali, Manaf, Barclay, Barry J., Bisson, William H., Cheng, Qiang, D'Abronzo, Leandro, Dornetshuber-Fleiss, Rita, Gosh, Paramita M., Gonalez-Guzman, Michael J., Lee, Tae-Jin, Leung, Po Sing, Li, Lin, Luanpitpong, Suidjit, Ratoviski, Edward, Rojanasakul, Yon, Romano, Maria Fiammetta, Romano, Simona, Sinha, Kumar Ranjeet, Yedjou, Clement, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Ryan, Elizabeth P., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Salem, Hosni K., Woodrick, Jordan, Scovassi, Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Kim, Seo Yun, Lowe, Leroy, and Park, Hyun Ho
Abstract:: Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...
Resource Type:: Article
Full Text:: environmental chemicals and cellular mechanisms that confer resistance to cell death Disruptive environmental

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Creator:: Dearstyne, Erica A.
Resource Type:: Dissertation
Full Text:: mechanism(s). We tested the hypothesis that induction of cell death is a mechanism by which TCDD causes a

BacMolBiol-1.F&T.051009.ppt

Creator:: Rohrmann, George F.
Full Text:: production of the baculovirus RNA polymerase. * Fig. 7.2. Cell death regulation by baculovirus

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Creator:: Hau, Andrew M., Greenwood, Jeffrey A., Lohr, Christiane V., Serrill, Jeffrey D., Proteau, Philip J., Ganley, Ian G., McPhail, Kerry L., and Ishmael, Jane E.
Abstract:: Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
Resource Type:: Article
Full Text:: Autophagy and Cell Death in Human Glioblastoma Cells Andrew M. Hau1, Jeffrey A. Greenwood2, Christiane V

Site-directed mutagenesis of chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) in different functional domain

Creator:: Wang, Zhaohong
Resource Type:: Masters Thesis
Full Text:: preadipocyte cell line, these mutations will be useful to study the molecular mechanism(s) of COUP-TF

Investigation of autophagy-assisted cell death in response to the cancer cell toxin coibamide A

Creator:: Tan, Michelle
Abstract:: Autophagy, a homeostatic degradation pathway, has a role in promoting cell survival under stress conditions, but can also promote cell death under conditions of sustained stress. This project investigates the cytotoxic potential of coibamide A and other natural products in autophagy-deficient and wild-type mouse embryonic fibroblasts (MEFs). Wild-type MEFs were...
Resource Type:: Honors College Thesis
Full Text:: Investigation of Autophagy-assisted Cell Death in Response to

ScholarsArchive@OSU

Mitochondrial glutathione and the effect of perturbed calcium homeostasis on rat hepatocyte thiols

Menage a trois : an evolutionary interplay between human papilloma virus, a tumor and a woman

Zebrafish models for translational neuroscience research: from tank to bedside

Use of γ-Glutamyltranspeptidase-deficient knockout mice as a model to study the relationship between glutathione status, mitochondrial dysfunction, and cell death

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

BacMolBiol-1.F&T.051009.ppt

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Site-directed mutagenesis of chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) in different functional domain

Investigation of autophagy-assisted cell death in response to the cancer cell toxin coibamide A

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