Perinatal growth restriction programs higher risk for chronic disease during adulthood
via morphological and physiological changes in organ systems. Perinatal growth
restriction is highly correlated with a decreased nephron number, altered renal function
and subsequent hypertension. We hypothesize that such renal maladaptations result in
altered pharmacologic patterns for life. Maternal...
Perinatal growth restriction programs higher risk for chronic disease during adulthood
via morphological and physiological changes in organ systems. Perinatal growth
restriction is highly correlated with a decreased nephron number, altered renal function
and subsequent hypertension. We hypothesize that such renal maladaptations result in
altered pharmacologic patterns for life. Maternal...
Full Text:
, BSa, Jacob Pearson, BSa, Tahir Mahmooda, Duc Nguyen, BSa, Kent
Thornburg, PhDb,c, and GaneshCherala
OBJECTIVE: Pharmacokinetic interactions exist between combined
oral contraceptives and protease inhibitors (PI). However, such
information is lacking for progestin-only oral contraception. We
sought to define the steady-state pharmacokinetic interaction between
norethindrone (NET) and PI in HIV-infected women.
METHODS AND DESIGN: We conducted an open-label, prospective,
nonrandomized trial to characterize the...
Perinatal growth restriction programs higher risk for chronic disease during adulthood
via morphological and physiological changes in organ systems. Perinatal growth
restriction is highly correlated with a decreased nephron number, altered renal function
and subsequent hypertension. We hypothesize that such renal maladaptations result in
altered pharmacologic patterns for life. Maternal...