In 1994, with the approval of the Northwest Forest Plan, the livelihood of individuals in the surrounding communities of the Siuslaw National Forest and Siuslaw Watershed were further impacted by already diminished traditional timber practices. In 2003, the United States Forest Service developed an innovative program, stewardship contracting, aimed at...
DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
Aim: There is growing interest in pharmacologic ascorbate (Asc) and its therapeutic properties (Levine et al. Adv Nutr 2011;2:78). W e examined cell viability, histone deacetylase (HDAC) expression, and related protein modifications in cancer versus non- cancer colon epithelial cells following exposure to Asc.
Methods: MTT assays were conducted in...
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
The Botija Cu-Mo-Au porphyry deposit is located in the Cobre Panamá mining district, which contains several deposits with a global measure and indicated and inferred resource of 14.8 MT of Cu. These deposits are associated with the Cerro Petaquilla batholith, which has U/Pb zircon ages of 26-33 Ma (Whattam et...
Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
The DNA mismatch repair (MMR) pathway maintains genomic stability and
reduces cancer risk (colorectal and other internal cancers) by correcting polymerase
errors and activating cell cycle checkpoints and apoptosis in response to DNA damage.
Few studies have examined the influence of commonly encountered environmental
mutagens/carcinogens on the etiology of MMR-deficient...
DNA mismatch repair (MMR) is an evolutionarily conserved process used by cells to decrease mutation rates, thereby increasing genetic stability and reducing cancer risk. Germline mutations in the MMR gene MLH1 have been identified in Lynch Syndrome patients, and in many cases are suspected but not confirmed as causative for...
Mismatch repair (MMR) system performs mainly three roles to maintain
genomic stability, correct DNA biosynthetic errors, ensure the fidelity of
genetic recombination, and in mammalian cells participate in the cellular
response to some DNA damages. Deficiencies in mismatch repair increase
mutation rates and cancer risks. In eukaryotes, the MMR system...