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- Creator:
- Hu, Zhiwei, Brooks, Samira A., Dormoy, Valérian, Hsu, Chia-Wen, Hsu, Hsue-Yin, Lin, Liang-Tzung, Massfelder, Thierry, Rathmell, W. Kimryn, Xia, Menghang, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Prudhomme, Kalan R., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Lowe, Leroy, Jensen, Lasse, Bisson, William H., and Kleinstreuer, Nicole
- Abstract:
- One of the important ‘hallmarks’ of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors and antiangiogenic factors. However, factors produced by cancer...
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- Article
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- , Annamaria Colacci11, Roslida A.Hamid12, Chiara Mondello13, Jayadev Raju14, Elizabeth P. Ryan9, Jordan
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- Creator:
- Carnero, Amancio, Blanco-Aparicio, Carmen, Kondoh, Hiroshi, Lleonart, Matilde E., Martinez-Leal, Juan Fernando, Mondello, Chiara, Scovassi, A. Ivana, Bisson, William H., Amedei, Amedeo, Roy, Rabindra, Woodrick, Jordan, Colacci, Annamaria, Vaccari, Monica, Raju, Jayadev, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Salem, Hosni K., Memeo, Lorenzo, Forte, Stefano, Singh, Neetu, Hamid, Roslida A., Ryan, Elizabeth P., Brown, Dustin G., Wise, John P., Sr., Wise, Sandra S., and Yasaei, Hemad
- Abstract:
- Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...
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- Article
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- , Annamaria Colacci9, Monica Vaccari9, Jayadev Raju10, Fahd Al-Mulla11, Rabeah Al- Temaimi11, Hosni K. Salem12
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- Creator:
- Thompson, Patricia A., Khatami, Mahin, Baglole, Carolyn J., Jun Sun,, Harris, Shelley A., Moon, Eun-Yi, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Brown, Dustin G., Colacci, Annamaria, Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Amedei, Amedeo, Hamid, Roslida A., Lowe, Leroy, Guarnieri, Tiziana, and Bisson, William H.
- Abstract:
- An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is...
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- Article
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- , Shelley Harris4, Eun-Yi Moon5, Fahd Al-Mulla6, Rabeah Al-Temaimi6, Dustin Brown7, Annamaria Colacci8
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- Creator:
- Nahta, Rita, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Andrade-Vieira, Rafaela, Bay, Sarah N., Brown, Dustin G., Calaf, Gloria M., Castellino, Robert C., Cohen-Solal, Karine A., Colacci, Annamaria, Cruickshanks, Nichola, Dent, Paul, Di Fiore, Riccardo, Forte, Stefano, Goldberg, Gary S., Hamid, Roslida A., Krishnan, Harini, Laird, Dale W., Lasfar, Ahmed, Marignani, Paola A., Memeo, Lorenzo, Mondello, Chiara, Naus, Christian C., Ponce-Cusi, Richard, Raju, Jayadev, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Vento, Renza, Vondráček, Jan, Wade, Mark, Woodrick, Jordan, and Bisson, William H.
- Abstract:
- As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth...
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- Article
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- , Gloria M.Calaf6,7, Robert C.Castellino8, Karine A.Cohen-Solal9, Annamaria Colacci10, Nichola
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- Creator:
- Casey, Stephanie C., Vaccari, Monica, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Barcellos-Hoff, Mary Helen, Brown, Dustin G., Chapellier, Marion, Christopher, Joseph, Curran, Colleen S., Forte, Stefano, Hamid, Roslida A., Heneberg, Petr, Koch, Daniel C., Krishnakumar, P. K., Laconi, Ezio, Maguer-Satta, Veronique, Marongiu, Fabio, Memeo, Lorenzo, Mondello, Chiara, Raju, Jayadev, Roman, Jesse, Roy, Rabindra, Ryan, Elizabeth P., Ryeom, Sandra, Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Soucek, Laura, Vermeulen, Louis, Whitfield, Jonathan R., Woodrick, Jordan, Colacci, Annamaria, Bisson, William H., and Felsher, Dean W.
- Abstract:
- Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects...
- Resource Type:
- Article
- Full Text:
- , Louis Vermeulen23, Jonathan R.Whitfield22, Jordan Woodrick18, Annamaria Colacci1, William H.Bisson24
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- Creator:
- Narayanan, Kannan Badri, Ali, Manaf, Barclay, Barry J., Bisson, William H., Cheng, Qiang, D'Abronzo, Leandro, Dornetshuber-Fleiss, Rita, Gosh, Paramita M., Gonalez-Guzman, Michael J., Lee, Tae-Jin, Leung, Po Sing, Li, Lin, Luanpitpong, Suidjit, Ratoviski, Edward, Rojanasakul, Yon, Romano, Maria Fiammetta, Romano, Simona, Sinha, Kumar Ranjeet, Yedjou, Clement, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Ryan, Elizabeth P., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Salem, Hosni K., Woodrick, Jordan, Scovassi, Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Kim, Seo Yun, Lowe, Leroy, and Park, Hyun Ho
- Abstract:
- Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...
- Resource Type:
- Article
- Full Text:
- , Annamaria Colacci18, Roslida A.Hamid19, Chiara Mondello20, Jayadev Raju21, Hosni K.Salem22, Jordan
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- Creator:
- Ochieng, Josiah, Nangami, Gladys N., Ogunkua, Olugbemiga, Miousse, Isabelle R., Koturbash, Igor, Odero-Marah, Valerie, McCawley, Lisa J., Nangia-Makker, Pratima, Ahmed, Nuzhat, Luqmani, Yunus, Chen, Zhenbang, Papagerakis, Silvana, Wolf, Gregory T., Dong, Chenfang, Zhou, Binhua P., Brown, Dustin G., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Amedei, Amedeo, Al-Temaimi, Rabeah, Al-Mulla, Fahd, Bisson, William H., and Eltom, Sakina E.
- Abstract:
- The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of lowdose environmental mixtures and carcinogens in the promotion of invasion and metastasis...
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- Article
- Full Text:
- Papagerakis7, Gregory T.Wolf7, Chenfang Dong8, Binhua P.Zhou8, Dustin G. Brown9, Annamaria Colacci10
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- Creator:
- Langie, Sabine A. S., Koppen, Gudrun, Desaulniers, Daniel, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Azqueta, Amaya, Bisson, William H., Brown, Dustin, Brunborg, Gunnar, Charles, Amelia K., Chen, Tao, Colacci, Annamaria, Darroudi, Firouz, Forte, Stefano, Gonzalez, Laetitia, Hamid, Roslida A., Knudsen, Lisbeth E., Leyns, Luc, Lopez de Cerain Salsamendi, Adela, Memeo, Lorenzo, Mondello, Chiara, Mothersill, Carmel, Olsen, Ann-Karin, Pavanello, Sofia, Raju, Jayadev, Rojas, Emilio, Roy, Rabindra, Ryan, Elizabeth, Ostrosky-Wegman, Patricia, Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Van Schooten, Frederik J., Valverde, Mahara, Woodrick, Jordan, Zhang, Luoping, van Larebeke, Nik, Kirsch-Volders, Micheline, and Collins, Andrew R.
- Abstract:
- Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome’s integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced...
- Resource Type:
- Article
- Full Text:
- H.Bisson5, Dustin Brown6, Gunnar Brunborg7, Amelia K.Charles8, Tao Chen9, Annamaria Colacci10, Firouz
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- Creator:
- Goodson, William H., III, Lowe, Leroy, Carpenter, David O., Gilbertson, Michael, Manaf Ali, Abdul, Lopez de Cerain Salsamendi, Adela, Lasfar, Ahmed, Carnero, Amancio, Azqueta, Amaya, Amedei, Amedeo, Charles, Amelia K., Collins, Andrew R., Ward, Andrew, Salzberg, Anna C., Colacci, Annamaria, Olsen, Ann-Karin, Berg, Arthur, Barclay, Barry J., Zhou, Binhua P., Blanco-Aparicio, Carmen, Baglole, Carolyn J., Dong, Chenfang, Mondello, Chiara, Hsu, Chia-Wen, Naus, Christian C., Yedjou, Clement, Curran, Colleen S., Laird, Dale W., Koch, Daniel C., Carlin, Danielle J., Felsher, Dean W., Roy, Debasish, Brown, Dustin G., Ratovitski, Edward, Ryan, Elizabeth P., Corsini, Emanuela, Rojas, Emilio, Moon, Eun-Yi, Laconi, Ezio, Marongiu, Fabio, Al-Mulla, Fahd, Chiaradonna, Ferdinando, Darroudi, Firouz, Martin, Francis L., Van Schooten, Frederik J., Goldberg, Gary S., Wagemaker, Gerard, Nangami, Gladys N., Calaf, Gloria M., Williams, Graeme P., Wolf, Gregory T., Koppen, Gudrun, Brunborg, Gunnar, Lyerly, H. Kim, Krishnan, Harini, Ab Hamid, Hasiah, Yasaei, Hemad, Sone, Hideko, Kondoh, Hiroshi, Salem, Hosni K., Hsu, Hsue-Yin, Park, Hyun Ho, Koturbash, Igor, Miousse, Isabelle R., Scovassi, A.Ivana, Klaunig, James E., Vondráček, Jan, Raju, Jayadev, Roman, Jesse, Wise, John P., Sr., Whitfield, Jonathan R., Woodrick, Jordan, Christopher, Joseph A., Ochieng, Josiah, Martinez-Leal, Juan F., Weisz, Judith, Kravchenko, Julia, Sun, Jun, Prudhomme, Kalan R., Narayanan, Kannan B., Cohen-Solal, Karine A., Moorwood, Kim, Gonzalez, Laetitia, Soucek, Laura, Jian, Le, D’Abronzo, Leandro S., Lin, Liang-Tzung, Li, Lin, Gulliver, Linda, McCawley, Lisa J., Memeo, Lorenzo, Vermeulen, Louis, Leyns, Luc, Zhang, Luoping, Valverde, Mahara, Khatami, Mahin, Romano, Maria F., Chapellier, Marion, Williams, Marc A., Wade, Mark, Manjili, Masoud H., Lleonart, Matilde E., Xia, Menghang, Gonzalez Guzman, Michael J., Karamouzis, Michalis V., Kirsch-Volders, Micheline, Vaccari, Monica, Kuemmerle, Nancy B., Singh, Neetu, Cruickshanks, Nichola, Kleinstreuer, Nicole, van Larebeke, Nik, Ahmed, Nuzhat, Ogunkua, Olugbemiga, Krishnakumar, P. K., Vadgama, Pankaj, Marignani, Paola A., Ghosh, Paramita M., Ostrosky-Wegman, Patricia, Thompson, Patricia A., Dent, Paul, Heneberg, Petr, Darbre, Philippa, Leung, Po Sing, Nangia-Makker, Pratima, Cheng, Qiang, Robey, R. Brooks, Al-Temaimi, Rabeah, Roy, Rabindra, Andrade-Vieira, Rafaela, Sinha, Ranjeet K., Mehta, Rekha, Vento, Renza, Di Fiore, Riccardo, Ponce-Cusi, Richard, Dornetshuber-Fleiss, Rita, Nahta, Rita, Castellino, Robert C., Palorini, Roberta, Hamid, Roslida A., Langie, Sabine A. S., Eltom, Sakina E., Brooks, Samira A., Ryeom, Sandra, Wise, Sandra S., Bay, Sarah N., Harris, Shelley A., Papagerakis, Silvana, Romano, Simona, Pavanello, Sofia, Eriksson, Staffan, Forte, Stefano, Casey, Stephanie C., Luanpitpong, Sudjit, Lee, Tae-Jin, Otsuki, Takemi, Chen, Tao, Massfelder, Thierry, Sanderson, Thomas, Guarnieri, Tiziana, Hultman, Tove, Dormoy, Valérian, Odero-Marah, Valerie, Sabbisetti, Venkata, Maguer-Satta, Veronique, Rathmell, W. Kimryn, Engström, Wilhelm, Decker, William K., Bisson, William H., Rojanasakul, Yon, Luqmani, Yunus, Chen, Zhenbang, and Hu, Zhiwei
- Abstract:
- Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that...
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- Article
- Full Text:
- , Andrew Ward12, Anna C.Salzberg13, Annamaria Colacci14, Ann-Karin Olsen15, Arthur Berg13, Barry