Breast cancer is a leading cause of cancer deaths among women, with an estimated 12.4% of American women diagnosed with this tumor type. Evidence suggests that exogenous disruptors can exert epigenetic changes leading to aberrant gene expression, shifting the cellular balance toward oncogenesis. While chemical pollutant exposure is well-studied, light...
Osteosarcoma (OSA) is a primary malignant bone tumor sarcoma that occurs in dogs as well as people and has aggressive biologic behavior with devastating consequences. Because of the similarities in morphology and prognosis, OSA in dogs represents an effective model for the equivalent disease in humans. Mesenchymal stem cells (MSCs)...
Luteinizing hormone (LH) is secreted in low-amplitude pulses in sexually intact dogs to stimulate synthesis of estrogen and testosterone in females and males, respectively. LH is mainly considered a reproductive hormone, but LH receptors (LHR) have been identified in non-reproductive tissues, including in canine lymphoma and isolated canine T-cell lymphoma...
Lymphoma (LSA) is one of the most common canine malignancies, and is almost invariably a terminal disease. Epigenetic changes in canine and human lymphomas have been linked to disease progression and poor prognosis, leading to the development of epigenetic-targeted therapies which have shown promise in treating various forms of human...