Although it is the first drug approved for usage to treat amyotrophic lateral sclerosis (ALS), riluzole’s mechanism of action is unknown and its therapeutic quality is hampered by its relatively short window of effectiveness. P2X7 is a purine receptor found in astrocytes and other cells, which increases calcium concentrations within...
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons in the motor cortex and spinal cord. Recent evidence suggests that the purine receptor P2X7 (P2X7R) plays a central role in the pathology of ALS. Previous research indicates that P2X7R activation by oxidatively modified heat shock protein 90...
Neurofibromatosis type 2 (NF2) is a genetic disorder caused by the inactivation of the
merlin tumor suppressor gene. NF2 patients develop bilateral vestibular schwannomas
(VS) and other nervous system tumors with no effective drug treatment option. In
pathological conditions, including NF2, production of the oxidant peroxynitrite leads to
protein tyrosine...
The status of many sea cucumber fisheries in the world is overexploited. Some of the reasons are: an increase in demand from China, the distance of these fisheries to China, and the high rate of fisheries development. Most sea cucumber fisheries are small-scale with a simple management system. To overcome overexploitation,...
True potato (Solanum tuberosum) seed (TPS) is used for preservation of variable genetic lines of wild and cultivated potatoes (Hawkes et al., 2000) and for propagation of food crops in some developing countries. TPS has advantages over seed potato tubers in storage and transportation and favors lower virus infection levels...
The relationship between the decomposition of trimethylamine
oxide in Pacific shrimp and shrimp meat quality was investigated to
evaluate the use of the trimethylamine oxide system as a quality
control indice.
Changes in the levels of trimethylamine oxide and its decomposition
products in whole shrimp stored on ice and in...
Data are presented on the life history of snake
pricklebacks, Lumpenus sagitta, collected in Yaquina Bay,
Oregon, from June 1977 to October 1978. Specimens were
collected primarily by beach seine from four sampling sites
in the bay. Snake pricklebacks feed on algae (mainly genus
Enteromorpha), on polychaeta (mainly genus Neoamphitrite),...
Empathy is considered a significant motivator of prosocial behavior. Increasing evidence suggests that feelings of personal distress associated with empathy may be stronger or weaker according to the form of perspective taking that an empathizer utilizes. The aim of the present study was to further quantify the stress consequences and...
Most regulations for recreational fishing in Mexico focus primarily on offshore boat fishing. However, regulations for inshore recreational fishing in Mexico are insufficient. Every year hundreds of European and American fishermen visit Punta Allen, Mexico to practice fly-fishing. Punta Allen is a coastal village located in the Sian Ka'an Biosphere...
In 2013 a stock of sea cucumber (Isostichopus badionotus) was discovered in northern shelf of Yucatan. A survey calculated a biomass of 17,600 tons. The species has an attractive price for local fishers, therefore, in order to avoid the “race for sea cucumbers” and the collapse of the stock, authorities...