Index Catalog // ScholarsArchive@OSU

Immunomodulatory Actions of Bovine Whey Protein Isolates, Glycomacropeptide, and Their Digests: Insights from Macrophage and Human Studies

Creator:: Olsen, Wyatt
Abstract:: Whey protein isolate (WPI) and glycomacropeptide (GMP) have shown potential immunomodulatory properties. In this study, we investigated their effects on pro-inflammatory cytokine secretion using both in vitro and in vivo models. In LPS-stimulated THP-1-derived macrophages, digested WPI and GMP reduced cytokine expression, while whole GMP increased secretion. The in human...
Resource Type:: Masters Thesis
Full Text:: and in vivo digests Wyatt Olsen1, Ningjian Liang2, David C. Dallas* 1,2 1Department of Food

Identifying Differences in the Release of Bioactive Milk Peptides Across the Intestinal Tract Between Term and Preterm Infants

Creator:: Beverly, Robert L.
Abstract:: Premature birth interrupts the typical development of the human fetus, leaving the infant born with underdeveloped gastrointestinal and immune systems. Preterm infants have reduced stomach acidity, reduced digestive protease activity, more permeable intestinal membranes, impaired innate and adaptive immune response, and poor microbiome development. Due to these factors, preterm infants...
Resource Type:: Dissertation
Full Text:: : ________________________________________________________________________ David C. Dallas Premature birth interrupts the typical

Analysis of Alternative Donor Breast Milk Pasteurization Techniques and Their Impact on Bile Salt-Stimulated Lipase Activity

Creator:: Victor, Ashley F.
Abstract:: While breast milk is considered the best nourishment for newborns, they have a lowered ability to digest the fat rich liquid due to decreased lipase secretion for the first few months after birth. To offset this, breast milk itself contains Bile Salt-Stimulated Lipase (BSSL) which significantly heightens fat digestion ability....
Resource Type:: Honors College Thesis
Full Text:: . APPROVED: _____________________________________________________________________ David C Dallas

Bovine Kappa-Casein Glycomacropeptide: Its Effects on the Microbiome, Inflammation and the Potential in Irritable Bowel Syndrome Management

Creator:: Qu, Yunyao
Abstract:: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder experienced by 10–15% of the global population, manifesting as chronic abdominal pain, bloating and inconsistent bowel habits. The search for effective treatments remains ongoing. One promising contender in this realm is kappa-casein glycomacropeptide (GMP), a milk-derived peptide. Its potential benefits stem...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ David C. Dallas

Effects of Whey Protein Isolate on the Human Gut Microbiota and Intestinal Function in Older Adults

Creator:: Rackerby, Bryna
Abstract:: Whey protein is a functional food comprised of numerous bioactive peptides and proteins, including glycomacropeptide (GMP), a hydrophilic casein peptide that separates with the whey fraction during cheesemaking. GMP has a unique amino acid composition, making it a viable nutritional therapy in disorders where certain amino acids are implicated, while...
Resource Type:: Masters Thesis
Full Text:: prebiotic properties of whey protein and glycomacropeptide Bryna Rackerby1, Si Hong Park1, *David C

Effects of Whey Protein Consumption on Inflammatory Biomarker Levels in Healthy Older Adults

Creator:: Adler, Samuel
Abstract:: Whey protein’s potential for bioactivity is well documented, but there is disagreement on the extent to which it may modulate the immune system towards decreased inflammation. Decreased inflammation is generally perceived as a beneficial bioactivity in foods as excessive chronic inflammation is linked to morbidity and mortality. This thesis first...
Resource Type:: Masters Thesis
Full Text:: Levels in Healthy Older Adults Abstract approved: David C. Dallas Abstract: Whey

Identification of Bitter Peptides in Aged Cheddar Cheese

Creator:: Kuhfeld, Russell
Abstract:: Bitterness is a common flavor attribute of aged cheese, but excessive levels are a flaw leading to consumer rejection. Bitterness in cheese has been primarily associated with milk casein-derived peptides of medium size (500–3,000 Da) and relative hydrophobicity. Herein, we demonstrate a novel approach for the identification of bitter peptides...
Resource Type:: Masters Thesis
Full Text:: : ______________________________________________________ David Dallas Excessive bitterness is an undesirable characteristic of aged cheese, which can

The immunomodulatory properties of glycomacropeptide in THP-1 macrophage study

Creator:: McAllister, Emily R.
Abstract:: Glycomacropeptide (GMP) is a bioactive peptide found in the dairy product whey, along with whey protein isolate (WPI). Past studies have shown that digested GMP retains bioactivity in rodent guts. This study tested whether GMP or GMP-derived peptides or whey protein or whey protein-derived peptides inhibit pro-inflammatory cytokines. THP-1 cells...
Resource Type:: Honors College Thesis
Full Text:: Abstract approved:_____________________________________________________ David Dallas Glycomacropeptide

Analysis of Intact Glycomacropeptide Derived from Bovine Kappa-casein in Whey Protein Isolate and Intestinal Digesta

Creator:: Qu, Yunyao
Abstract:: Kappa-casein glycomacropeptide (CMP), a 64-amino-acid peptide, is released from kappa-casein after rennet treatment and is one of the major peptides in whey protein isolate (WPI). CMP has anti-inflammatory and antibacterial activities. CMP has two major amino acid sequences with different modifications including glycosylation, phosphorylation and oxidation. However, no previous work...
Resource Type:: Masters Thesis
Full Text:: LC-MS/MS Authors: Yunyao Qua, Bum Jin Kimb, Jeewon Kohb, David C. Dallasab Affiliations

Effects of Galactooligosaccharides on the Gut Microbiota in Lactose Intolerant Individuals

Creator:: Angima, Gloria
Abstract:: Lactose intolerance is a common food intolerance that occurs because of a post-weaning deficiency of lactase, an enzyme that cleaves the glyosidic bond of lactose. About 75% of the world's population is lactose intolerant. Common symptoms of lactose intolerance are abdominal pain, bloating and diarrhea. ~25% of the world’s population...
Resource Type:: Masters Thesis
Full Text:: Park1, David C. Dallas1,2 1Department of Food Science and Technology, Oregon State University

ScholarsArchive@OSU

Immunomodulatory Actions of Bovine Whey Protein Isolates, Glycomacropeptide, and Their Digests: Insights from Macrophage and Human Studies

Identifying Differences in the Release of Bioactive Milk Peptides Across the Intestinal Tract Between Term and Preterm Infants

Analysis of Alternative Donor Breast Milk Pasteurization Techniques and Their Impact on Bile Salt-Stimulated Lipase Activity

Bovine Kappa-Casein Glycomacropeptide: Its Effects on the Microbiome, Inflammation and the Potential in Irritable Bowel Syndrome Management

Effects of Whey Protein Isolate on the Human Gut Microbiota and Intestinal Function in Older Adults

Effects of Whey Protein Consumption on Inflammatory Biomarker Levels in Healthy Older Adults

Identification of Bitter Peptides in Aged Cheddar Cheese

The immunomodulatory properties of glycomacropeptide in THP-1 macrophage study

Analysis of Intact Glycomacropeptide Derived from Bovine Kappa-casein in Whey Protein Isolate and Intestinal Digesta

Effects of Galactooligosaccharides on the Gut Microbiota in Lactose Intolerant Individuals

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