Index Catalog // ScholarsArchive@OSU

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation
Full Text:: : Roderick H. Dashwood Histone deacetylase (HDAC) inhibitors have the potential to de‐repress

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation
Full Text:: : ___________________________________________________________ Roderick H. Dashwood Met is a prognostic indicator of colorectal cancer patient survival

Functional analysis of novel β-catenin mutants

Creator:: Al-Fageeh, Mohamed B.
Abstract:: β-catenin is a multi functional protein that is involved in cell-cell adhesion and cell signaling. In non-stimulated cells, β-catenin is tightly down-regulated by GSK-3β-dependent phosphorylation at Ser and Thr residues, followed by rapid ubiquitination and proteasomal degradation. It is well established that mutations within the regulatory GSK-3β region lead to...
Resource Type:: Masters Thesis
Full Text:: : Functional Analysis of Novel -catenin Mutants Abstract approved Roderick H. Dashwood 13-catenin is a multi

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation
Full Text:: approved: Roderick H. Dashwood Emily Targeting the epigenome, including the use of histone deacetylase

R factor transfer among bacteria isolated from the environment

Creator:: Latimer, Joan Marie
Resource Type:: Masters Thesis
Full Text:: . L. Fryer R S S S S S S S Aeromonas Dr. R. H. McCoy liquefaciens 17 Media Organisms to be

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Creator:: Yu, Zhen
Abstract:: The antimutagenic potency of wheat grain and berry extracts was studied in vitro against several heterocyclic amines (HCAs) using the Salmonella mutagenicity assay and the anticarcinogencity of wheat grain was studied in vivo using the rat colonic aberrant crypt focus assay. Wheat bran, which binds HCAs in vitro, as well...
Resource Type:: Masters Thesis
Full Text:: Dr. Roderick H. Dashwood for their guidance, constructive criticism, advice, encouragement, patience

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:: Campbell, Yan
Abstract:: The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Resource Type:: Dissertation

The river of the West

Creator:: Victor, Francis Fuller
Abstract:: Gerald W. Williams Collection
Resource Type:: Book
Full Text:: ,. ' ' IFR, l e CE.rJDL."f ·rHE l3LuE l\1o ;.;,.TAJ J. .... ~ .... , - Tu r~ Bl~A H 1 .. ,. A~lP, - - ~ A'II

Kaiser_Matthew Project Presentation vPDF.pdf

Creator:: Kaiser, Matthew Carl, Rajendran, Praveen, Dashwood, Mohaiza W., Levine, Mark A., Michels, Alexander, Frei, Balz, and Dashwood, Roderick H.
Abstract:: Aim: There is growing interest in pharmacologic ascorbate (Asc) and its therapeutic properties (Levine et al. Adv Nutr 2011;2:78). W e examined cell viability, histone deacetylase (HDAC) expression, and related protein modifications in cancer versus non- cancer colon epithelial cells following exposure to Asc. Methods: MTT assays were conducted in...
Full Text:: Colon Cancer Matthew Kaiser Frei Lab & Dashwood Lab “Epigenetics refers to changes in gene

Kaiser_Matthew Project Presentation.pptx

Creator:: Kaiser, Matthew Carl, Rajendran, Praveen, Dashwood, Mohaiza W., Levine, Mark A., Michels, Alexander, Frei, Balz, and Dashwood, Roderick H.
Abstract:: Aim: There is growing interest in pharmacologic ascorbate (Asc) and its therapeutic properties (Levine et al. Adv Nutr 2011;2:78). W e examined cell viability, histone deacetylase (HDAC) expression, and related protein modifications in cancer versus non- cancer colon epithelial cells following exposure to Asc. Methods: MTT assays were conducted in...
Full Text:: Kaiser Frei Lab & Dashwood Lab “Epigenetics refers to changes in gene expression caused by mechanisms

ScholarsArchive@OSU

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Functional analysis of novel β-catenin mutants

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

R factor transfer among bacteria isolated from the environment

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

The river of the West

Kaiser_Matthew Project Presentation vPDF.pdf

Kaiser_Matthew Project Presentation.pptx

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