Pandemic influenza viruses modulate proinflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites, and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Integrative analysis of high-throughput omics data with virologic and histopathologic data...
In this work, flow through synthetic arrangements of contacting spheres is studied
as a model problem for porous media and packed bed type flows. Direct numerical
simulations are performed for moderate pore Reynolds numbers in the range,
10 ≤ Re ≤ 600, where non-linear porescale flow features are known to...
Humans have always been fascinated with whales; from prominent features in mythology, to stories of terrifying monsters on the high seas, to globalized utility, to symbolic wildness and radical environmentalism, to figures and statistics, how have human relationships with whales been understood throughout time? Because humans have a need to...
In this dissertation, I present experimental observations of multiply charged atomic ions (MCAI) generated from interactions of atomic/molecular clusters with moderately intense nanosecond laser pulses. This process is also known as Coulomb explosion (CE) and it has been extensively studied in intense laser fields using ultrashort pulses. Several prevailing theories...
Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...