Corneal ulcers are one of the most common eye conditions of the horse, with potentially serious complications such as loss of vision or the eye itself. They are extremely painful due to the large number of sensory nerve endings found in the cornea. Horses frequently show signs of ophthalmic pain...
Lactate is an end-product of both aerobic and anaerobic glycolysis and it can be used as an energy source for tissues. It is produced by all cells in the mammalian body that can metabolize glucose. Increased production of lactate can be seen with there is an increase in cellular metabolism...
Adult onset progressive alopecia and leukotrichia developed in 2 registered black Angus cows, aged 6 and 7
years. Histopathologic findings in skin were prominent melanin clumping and degeneration of matrix cells with formation
of giant multinucleate cells within hair bulbs, accompanied by peribulbar melanin incontinence and fibrosis and dystrophic
hair...
Over a 3.5-year period, 4 Rocky Mountain goats (Oreamnos americanus), housed at a single facility, developed clinical disease attributed to infection by Caprine arthritis encephalitis virus (CAEV). Ages ranged from 1 to 10 years. Three of the goats, a 1-year-old female, a 2-year-old male, and a 5-year-old male, had been...
INTRODUCTION: Tissue engineering is a new methodology for addressing meniscal
injury or loss. Synovium may be an ideal source of cells for in vitro meniscal fibrocartilage
formation, however, favorable in vitro culture conditions for synovium must be
established in order to achieve this goal. The objective of this study was...
Previous investigations have failed to show benefits of low level laser therapy (LLLT) for tendon healing in horses, contrary to reports in other species. We hypothesized that delivery of LLLT at manufacturer-recommended energy fluence through equine cadaver skin to equine tendon-derived fibroblasts in vitro would increase cell proliferation, metabolic activity...
The objective of this study was to elucidate the expression of signaling molecules associated with the Wnt signaling pathway in cartilage of prepubescent foals and determine their association with chondrocytes located at the osteochondral junction and cartilage canals. Our hypothesis was that increased expression of the components of the Wnt...
The first part of the dissertation is to evaluate the use of proposed and established equations for area under the plasma concentration versus time (AUC) for molecules undergoing nonlinear Michaelis–Menten pharmacokinetic elimination. The effects of varying Michaelis-Menten parameters, rate of drug absorption, or bioavailability on the predictability of drug exposure...