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  • Deoxyribonucleotides as Genetic and Metabolic Regulators

    Creator:
    Mathews, Christopher K.
    Abstract:
    For more than 35 years we have known that the accuracy of DNA replication is controlled in large part by the relative concentrations of the four canonical deoxyribonucleoside 5'-triphosphates (dNTPs) at the replisome. Since this field was last reviewed, about eight years ago, there has been increased understanding of the...
    Resource Type:
    Article
    Full Text:
    Federation of American Societies for Experimental Biology Accepted Manuscript http

  • The Role of Cellular Senescence in the Development of Alzheimer's Disease

    Creator:
    Riordan, Ruben
    Abstract:
    Alzheimer’s Disease (AD) is a neurodegenerative pathology currently affecting nearly 44 million individuals worldwide, yet there are not currently any effective treatments or preventions for AD despite the rapid development in our understanding of the disease over the last four decades. The medical and sanitary innovations of the last century...
    Resource Type:
    Dissertation
    Full Text:
    research is focused on identifying and understanding the mechanisms of the aging process, which

  • The aging endoplasmic reticulum

    Creator:
    Dixon, Brian M.
    Abstract:
    Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
    Resource Type:
    Dissertation
    Full Text:
    and Cellular Biology presented on March 20, 2008 Title: The Aging Endoplasmic Reticulum

  • Influence of post-mortem aging upon some chemical characteristics of tropomyosin preparations from bovine skeletal muscle

    Creator:
    Dewey, James Edward
    Resource Type:
    Dissertation
    Full Text:
    tropomyosin could then be responsible for the tenderization of muscle during aging. 15 EXPERIMENTAL

  • MicroRNAs control neurobehavioral development and function in zebrafish

    Creator:
    Tal, Tamara L., Franzosa, Jill A., Tilton, Susan C., Philbrick, Kenneth A., Iwaniec, Urszula T., Turner, Russell T., Waters, Katrina M., and Tanguay, Robert L.
    Abstract:
    microRNAs (miRNAs) have emerged as regulators of a broad spectrum of neurodevelopmental processes, including brain morphogenesis, neuronal differentiation, and survival. While the role of miRNAs in establishing and maintaining the developing nervous system is widely appreciated, the developmental neurobehavioral role of miRNAs has yet to be defined. Here we show...
    Resource Type:
    Article
    Full Text:
    The FASEB Journal • Research Communication MicroRNAs

  • Investigating connections between the circadian system and aging in Drosophila melanogaster

    Creator:
    Long, Dani M.
    Abstract:
    Circadian clocks coordinate molecular, cellular, physiological, and behavioral processes with the 24-hour solar day. While clock functions are well understood in young animals, it is not clear how aging or neurodegenerative disease affects the various levels of the circadian system. A common symptom of many neurodegenerative diseases including Alzheimer’s disease...
    Resource Type:
    Dissertation
    Full Text:
    : Investigating Connections Between the Circadian System and Aging in Drosophila melanogaster. Abstract

  • Crystallin proteolysis in lens during aging and cataract formation

    Creator:
    Ueda, Yoji
    Abstract:
    The major purpose of this research was to characterize partially degraded proteins appearing in the ocular lens during aging and cataract, and to identify the responsible proteolytic activities. This research is significant, because increased protein degradation is associated with lens opacification and cataract. Determining the sites where lens proteins become...
    Resource Type:
    Dissertation
    Full Text:
    Crystallin proteolysis in lens during aging and cataract

  • Aging and oxidative damage to mitochondrial membrane proteins

    Creator:
    Tong, Tony T.
    Abstract:
    Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
    Resource Type:
    Honors College Thesis
    Full Text:
    Aging and Oxidative Damage to Mitochondrial

  • Exploring Links between Circadian Rhythms and Healthy Aging

    Creator:
    Mattison, Braden J.
    Abstract:
    Circadian rhythms are the daily oscillations in multiple organism functions, from clock gene expression to behavior. Lost or irregular rhythms lead to health problems later in life including nervous system disorders, abnormal sleep/activity cycles, diabetes and obesity. However, it is not known whether strengthening the expression of clock genes throughout...
    Resource Type:
    Honors College Thesis
    Full Text:
    Exploring Links between Circadian Rhythms and Healthy Aging

  • Biochemical study of aging in seeds

    Creator:
    Abu-Shakra, Salah Suleiman
    Abstract:
    A biochemical study of aging was conducted on mitochondria from the embryo axes of germinating new and old soybean seeds. Differential phosphorylative efficiency, an average P/O ratio of 3.03 of the new material compared to 1.44 of the old, was obtained when all the co-factors and substrate were provided. No...
    Resource Type:
    Dissertation
    Full Text:
    an im- portant factor in aging, there is no direct experimental evidence to support the validity